ID A0A3P9B8X3_9CICH Unreviewed; 1222 AA.
AC A0A3P9B8X3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=FERM and PDZ domain-containing protein 4 {ECO:0000313|Ensembl:ENSMZEP00005006340.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005006340.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005006340.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005006340.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P9B8X3; -.
DR STRING; 106582.ENSMZEP00005006340; -.
DR Ensembl; ENSMZET00005006629.1; ENSMZEP00005006340.1; ENSMZEG00005004889.1.
DR GeneTree; ENSGT00950000183035; -.
DR Proteomes; UP000265160; LG23.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13183; FERM_C_FRMPD1_FRMPD3_FRMPD4; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR049385; FAK1-like_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR041779; FRMPD1/3/4_FERM_C.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46221:SF4; FERM AND PDZ DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR46221; FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF21477; FERM_C_FAK1; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 1..75
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 124..439
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 500..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1134..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..722
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..904
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..931
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..959
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1222 AA; 135151 MW; 33305914DC8BC8E5 CRC64;
MRRDPVLGFG FVAGSEKPVV VRSVTPGGPS EGKLLPGDEI IMINDEPVSS APRERVIDLV
RSCKESIMLT VVQPYPSPKS AFISAAKKAM LKSNPVKVRF AEEVIINGQV PNPMKDNSLL
FMPNVLKVYL ENGQTKSFRF DCSTSIKEVI LTLQEKLSIK CIEHFSLVLE QRTEGSESKL
LLLHEQEMLT QVTQRPGCDK MKCFFRISFV PRDPVELLRR DAVAFEYLYV QSCNDVVLER
FGQELKYDAA LRLAALQMYI LTMTTRQSQK VSLKYIQKEW GLSLFLPPAV LSSMKEKNVK
KALTHILKTN QNLVPPGKKL TALQAKVHYL RYLSELRLFG GREFKSILLQ GEKQTEVTLL
VGPRYGISHV INARTNLVAL LADFSHVNRI EILTEDETNV RLELHVLDVR PITLIMESSD
AMNLACLTAG YYRLLVDSRR SIFSMAHCNS TGVDDLSKYD PCLCVGQGNM AKNIYHDIYL
KICDNFITDD IIDTRHNTLN SEYSDNGQRE NSISPYFHEP PNPDRDLENR RSPLPPPLPP
ATRHKTQDSP RSAKVSFIFE GNPPLNKCKN LRYERLLESP EVPNYGPPYL HNNTYFQQQD
REPFQHVYSN IISEESSEEL RELVYRGNTS DPDEDSCEED STGGTPVGDE THDATFLTLS
GSTDDIIDLT SLPPPEGDDG VDDDEDDTLL QTLNLAIAAP PPGFRDSLDE DVAPEGRPLS
TRENDDIPVS LIDAIPTHGE GEGSRGGERG LENAVMNTLQ ALQALSVSEQ KPPPPPPPSG
VYISHGFSPE SSSDSGNETN SSEMTEISEL AATHRLSESH MRLLVATREG YQPLIEEKTE
FPVSPSTGGT IQKKPRSPTR HLHPPAVPPR RSPQLSTTSS RPDSSEVRPQ TNLSATLQRP
SSTTPGGKHH KKSADSSGKY NTFSTREGYR GESIGSRSHL DLDQRTSFCE REDSQRRQDS
FLAENSVAES HGVNSLPRDH HRSPRPSSVI SDRFSDVVNL GGCDADNGAS AAEQDEHLVV
ASLLSPTKKS RSGGSDQGSD LQSDHQPISR QQSVARLCEY HLAKRISNLQ GEAHSSLQGS
LCSSLDAGGS TNSSVCATPN DSPLGPGAIE SKHHHLQRHP LSSSSSSLLR VLNYEDNKPG
TPFGTPAQST QGKDLHPHAD PALLRKMLQS SKNCEDVFGT SSWLPSLNCY QRGEVIVRHS
VGFKFRLTEA PQAEAGCKPR VL
//
