ID A0A3P9B953_9CICH Unreviewed; 886 AA.
AC A0A3P9B953;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Discs large homolog 1-like protein {ECO:0000313|Ensembl:ENSMZEP00005006415.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005006415.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005006415.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_004562164.1; XM_004562107.2.
DR AlphaFoldDB; A0A3P9B953; -.
DR Ensembl; ENSMZET00005006709.1; ENSMZEP00005006415.1; ENSMZEG00005004850.1.
DR GeneID; 101468517; -.
DR GeneTree; ENSGT00940000164867; -.
DR OrthoDB; 2879721at2759; -.
DR Proteomes; UP000265160; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd11861; SH3_DLG-like; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR InterPro; IPR016313; DLG1-like.
DR InterPro; IPR019590; DLG1_PEST_dom.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF33; DISKS LARGE HOMOLOG 4; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF10608; MAGUK_N_PEST; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF10600; PDZ_assoc; 1.
DR PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM01277; MAGUK_N_PEST; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 207..294
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 302..389
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 453..534
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 568..640
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 696..871
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 57..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..666
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 886 AA; 97992 MW; CD6919C42CB4B904 CRC64;
MLCHCKVACT NNTISLMFGC KKYRCQEEEG ASPGAPKLHH HPCQHHQMGV ARELREGSTL
GRDGGTLGRE GGTWRRDEGS AGTMERERER SLGRDGSLGR HNDLRGAELV QVAERQLSQI
QHVHGYVTHT HITPAQVESP EVSFDDEAWP HPEGERLNEV PAPPFSSLYS QSHAYYQANP
PPVVVNTDSV DTPPYVNGTE ADYEYEEITL ERGNSGLGFS IAGGTDNPHI GDDPSIFITK
IIPGGAAAQN GRLRVNDRIV RVNETDVREV THSGAVEALK EAGGLVRLCI RRRRSLTERI
LDIKLVKGPK GLGFSIAGGV GNQHVPGDNS IYVTKIIEGG AAHKDGRLQI GDKLVAVNGS
CLEEVTHEEA VAALKSTPDV VYLRVAKHTS LFINDNFPPP DVTNSYSPHQ DNHISPYMSG
SQSVSPAPLT TPRYSPLPRS IAGDDDITRE PRRVVLQRGS TGLGFNIVGG EDGEGIFISF
ILAGGPADLC GELRKGDRIL SVNGVDLSSA THEQAAAALK NAGQTVTIVA QFRPDEYSRF
EAKIHDLREQ MMTSSVSSSS TSLRSTQKRT LYVRALFDYD GSASDLSAPN QALPFHFGDI
LHVSSASEEE WWPARHLSPP PPNCPEVGVI PSRRRAEKKE RSRLKTVRVS RSQDRSDQDD
KELVYSGTSD NESSSSGQEE ILLTYQPVMQ HEVNYTRPVI VLGPMKDRVN DDLISEFPDK
FGSCVPHTTR PRRDYEVDGR DYHFMSSREL MEREIQEHKF IEAGQYNNHL YGTSIQSVKE
VADKGKHCIL DVSGNAIKRL QMAGLHPIAI LIRPLSVDNI LEMNKRLSEE QARKAYDRAV
KLEQEFTEYF TAIVQGSTLE EVYSQVKQII EEQSGPYIWV PTKERL
//