ID A0A3P9B963_9CICH Unreviewed; 831 AA.
AC A0A3P9B963;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Lethal(3)malignant brain tumor-like protein 4 {ECO:0000313|Ensembl:ENSMZEP00005006444.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005006444.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005006444.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3P9B963; -.
DR STRING; 106582.ENSMZEP00005006444; -.
DR Ensembl; ENSMZET00005006739.1; ENSMZEP00005006444.1; ENSMZEG00005004981.1.
DR GeneTree; ENSGT00940000158264; -.
DR Proteomes; UP000265160; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20103; MBT_L3MBTL1-like_rpt3; 1.
DR CDD; cd20135; MBT_L3MBTL3_rpt2; 1.
DR CDD; cd09582; SAM_Scm-like-3MBT3_4; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 4.10.320.30; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR002515; Znf_C2H2C.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF130; SAM DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02820; MBT; 3.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF01530; zf-C2HC; 1.
DR SMART; SM00561; MBT; 3.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 3.
DR PROSITE; PS51079; MBT; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS51802; ZF_CCHHC; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01143}.
FT REPEAT 244..344
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 352..451
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 460..555
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 764..828
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 831 AA; 90779 MW; C9F2266667A4C028 CRC64;
MTDTPPSDGP SQGAEFDRMG LDWKDGIATL PGSDIRFRLT EFRTLEIVTD LEVKGQEAEP
NSETLDPAPS HTPTPPPEGQ SQTGTSKASA NQSKPGLSQA KAPGPVLLSL EEGPSMEGPS
VEVGPSVEVG SSANLGSNGE LSRCRACGGR APGDALLQGK FCCSACAQPS SGRSSPGEAR
EGQAVEGERL GKRVRKKRKI YMDSGEEEEE NQEEPEEKAK ATKGRRGAKI AKLVAAPPNK
KRAWSWPSYL EEERAVAAPV KLFKEHQSLP QSRNSFKVGM KLEGLDPAHP SLFCVLSVAE
IQGYRVRLHF DGYPECYDFW ANADSWDLKP AGWCEKNGHK LLLPKGCKDG EFNWSTYVKN
CRGQLAPKHL FKSLNTSVTP SGFRAGMKLE AVDRKNPALI CVATIAAVVD NRLLIHFDNW
DDTHDYWCDA SSPYIHPVGY CEEAELTLTT PAECKEPKSF SWEKYLEETG TQAAPARAFK
VRPLHGFQFG MKVEAVDKRN PMLIRVATIA DTEDHRLKIH FDGWSSEYDY WVETDCPDLH
PVGWCQKTGH PLQYPNGSSD LVTAPGQGCP TPGCNGVGHI RGPRYGTHYT QVSCPYSEVN
LNKEGLLPDR LSGERPPTLS GPHPRGRRPD PNANNTTQNS STQDQPEGPE DAQNRKPATV
AAERTGRSSQ AEALSGATEQ SHNGTRPKRT APVPKYLKMH YVKEEIGDSK ASPEAISLQQ
ALHESVFSPG ISASPPHRVA LCWDKHCQLL PEVLGLTAKR VATWSAEEVA GFVKGLPGCK
EHAATFKTEQ IDGEAFLLLT QADIVKILSI KLGPALKIYN SILMLKNADE E
//
