ID A0A3P9B9V4_9CICH Unreviewed; 1351 AA.
AC A0A3P9B9V4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Roundabout homolog 2 {ECO:0000313|Ensembl:ENSMZEP00005006571.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005006571.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005006571.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005006571.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 106582.ENSMZEP00005006571; -.
DR Ensembl; ENSMZET00005006869.1; ENSMZEP00005006571.1; ENSMZEG00005005074.1.
DR GeneTree; ENSGT00940000155457; -.
DR Proteomes; UP000265160; LG14.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 3.
DR CDD; cd07693; IgC_1_Robo; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF37; ROUNDABOUT GUIDANCE RECEPTOR 3; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 4.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1351
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017965997"
FT TRANSMEM 858..880
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..125
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 131..218
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 223..307
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 312..405
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 416..502
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 522..617
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 636..728
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 733..831
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1085..1118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1210..1306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1089..1113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1272..1303
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1351 AA; 148128 MW; 41AA572A6B538D76 CRC64;
MNVANLLLVT VSFVSVSSGS RPRFEDSPPR IAEDPSDLIV SKGEPATLNC KAEGRPIPSI
EWYKDGERVE TDKDDPRSHR MLLPSGSLFF LRIVHGRRSK PDEGVYTCVA RNYLGEAISR
NASLEVAVLR DDFRQAPSDV VVAAGEPAVL ECVPPRGHPE PTVSWKRNNV RVSTKDERVT
MRGGKLMISH TRKSDAGMYV CVGSNMVGER DSDPAELVVY ERPVLVRRPV NQVVMEEETV
DFLCEVHGDP APTVRWRREE GELPRGRFEI RNGNNLRLFR VKEQDEGTYT CTSENSVGKT
EASAMLQVHV PPQIATKPRD QIATQGRSIT FQCGTTGNPP PAIFWQKEGS QMLLFPGQPP
SQSGRYSVSM NGELTITDVH PEDSGFYICQ AISVAGSVLT KALLEVEGGP SGRIPPIIRQ
GPANQTVSRG ATAQLYCRVN GGTSVEISWE KDGERLQGNT PRLTLMENGT LQIADVKDTD
SGMYTCVVSS TTGESSWSGM LTVRDGGSSV SRASEFIQLP GPPQKPVITE VTKNTVTLTW
QSNPHEGGAA VTSYIIEAFS QSVGSTWQTV ADHVKQERHT VVGLFPNTVY LFIVRAVNSY
GLSDPSPISE PVRTQDGSPT EQGVDHRQVQ RELGEVSVYL QKPMVLSPTS AKISWSVARQ
SRYVQGYRIF YRTIGSSWLV QDVEATSDYS TILADLHSGT EYEVKIRPYF NELQGHDSLM
VLLRTSEEVL CAPPQAVSVV QLTNSTSISV SWEPPPHNIQ SGIIREYKVW CLGSGVEQEN
QINRTVDGAV LSILLTGLLP EVRYTVMVAA VTSLGVGAQS PPVSLLLTPP LEKTSTTVTK
GDDLSIAEQI TSVILQPAFI AGLGVAAWLV LMGFSGWLYC RHRRRKQLGH YTTSFAYTPA
VGFAHSEGSG IINGGPGLLG SNMGNYPWLA DSWPTPNLTH NSKDSVNCCS GKLDSERYYN
TVGIINYPNQ SEKHSAASND SPIYSTINTT AEDDLLAYYD TYSSTSYNQG PDPYSSNPIL
SNSGFGGLEQ DLDHWTIKSG HSGSEYAKLQ YSKKSNDKLV KQRSTGTSSK SGPLTWVDVL
SLPLPTNKDG HHTKTHKEDE QHSSEEEDDD WCPPLPARTY LMDTSREELP SLPSKPDELS
YTATLTSPHQ QDASKPNDSP RLQHFDLLAR HHLVSQSNPD LFTNMKAQDG SEVYRTSQWV
DDFKGESLGK GQFPVTAAES SPTAPAHRSK SKKKTPKDGP NKRDLQSEAE LPPPPAPLRT
DDSLQLLADV LSRSRADKEG SDSPTLQKRG EHFSPERRGS TKWLSQDENV IPYGQSSIVP
NVQTSNYGSL GGGVFQQPSS AGLRRNEVHW G
//