ID A0A3P9BAA5_9CICH Unreviewed; 2162 AA.
AC A0A3P9BAA5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Sidekick cell adhesion molecule 2 {ECO:0000313|Ensembl:ENSMZEP00005006807.1};
GN Name=SDK2 {ECO:0000313|Ensembl:ENSMZEP00005006807.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005006807.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005006807.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005006807.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSMZET00005007108.1; ENSMZEP00005006807.1; ENSMZEG00005005116.1.
DR GeneTree; ENSGT00940000155761; -.
DR Proteomes; UP000265160; LG8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 13.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 19.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF46; PROTEIN SIDEKICK-1 ISOFORM X1; 1.
DR Pfam; PF00041; fn3; 13.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 13.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 7.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 13.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1896..1919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 93..152
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 167..249
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 260..350
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 354..443
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 448..539
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 544..640
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 645..741
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 746..845
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 849..943
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 947..1046
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1051..1149
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1154..1251
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1255..1349
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1354..1451
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1456..1571
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1576..1672
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1676..1787
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1790..1888
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1030..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1138..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1975..1994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2006..2033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2065..2162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2006..2026
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2079..2099
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2100..2145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2162 AA; 238398 MW; 5CB0734373DA7DD1 CRC64;
MAEGSWPLEF KWIHNSTELT RFSLEYRYLI PSLDRSHAGF YRCIVRNRVG ALLQRRTEVQ
VAFMGSFEEG ERTQSVSQGE GAVIPAPRIR SFPQPQVTWF RDGRKIPPSS RIAITLDNTL
VILSTVAPDA GRYYVQAVND KNGENKTSQP ITLSVENVGG PADPIAPTII IPPRNTSVVT
GTSEVTMECV ANARPLIKLS ITWRKNGVLV NSGLSDFNRR LTILSPVVSD AGYYECEAIL
RSSSVPSVSA GAYLHVLEPP QFIKEPEKHI TAEMEKVVDI PCQARGVPQP DIVWYKDALP
IDPVRTPRYR VLVGGSLQVN GLLPDDTGMF QCFARNLAGE VQTNTYLAVT SIAPNITAGP
SDSTVIDGMS VILHCETSGA PRPAITWQKG ERVLASGSVQ LPRFTLLESG SLLISPSHIS
DAGTYTCMAS NSRGIDEASA DLVVWARTRI TTPPQDQSVI KGTKAIMNCG VTHDPSVTVR
HVWEKEGSVI NVQSIPRMRL DADGTLHISQ TWSGDIGTYT CRVTSVGGND SRSAHLRVRQ
LPHAPENPTA VLSKSEKRAI DLAWAKPFDG NSPLIRYILE VSENNAPWAI LLANIEPEST
AVTVNGLIPA RSYQFRLCAV NDVGKGQFSK ETDRVSLPEE SPSAPPQNVI ASGRTNQSIM
IQWQPPPESH QNGILRGYIV RYRLTGLPVD YQIKNISSPD MTTLLLEDLI IWTNYEIEVA
AYNGAGLGTF SHKVTEWTLQ GVPTIAPGNV QAESVNSTTI RFTWAAPNPQ FINGINQGYK
LLAWEPGKDD EVAMVTVRPN FQDSVHVGYV TGLKKFTEYY TSVLCFTTPG DGPRSPPKAL
RTHEDTPGAV GHLSFTEILD TSLKVSWSEP SEKNGVLTGY RISWEEYNRT NTRVTHYLPN
VTLEYRVTGL TALTTYTIEV GGMTSKGQGV LSSSTISSGV PPELPGPPTN MAISNIGPRS
INLQFKPGYD GKTSISRWLV EAQVGAVGEN EDWLMVHQVF NEPEARSLEV PGLNPYTSYR
FRMRQVNIVG TSPPSQPSRK IQTLPAPPDM APANVTLRTA SETSLWLRWM PLPEWEYNGN
AEQVGYRVQY SRAGSQGHPL THVITDRLER EFTIEDLEEW TEYEVRVQAV NGIGVGPWSQ
PVRGRTRESV PSSGPTNVSA FATTSSSILV RWFEVPEPDR NGLILGYKVV YKEKDSDSPV
HFWTVEGNAT HSVQLTGLGK YVLYEIQVLA FTRIGDGRPS SPPILERTLD DVPGPPVGIL
FPEVRTTSVR LIWQSPAQPN GIILAYQITY HLNSTNSNTA TVDVLNPSAR QYMVTNLKPE
TVYVFRITAQ TRKGWGEAAE ALVVTTEKRA RPQPTSRPLV PQKHVQARQV LLSWEPGSDG
LSPVRYYTVQ LRELPESNWT VHSASVSHEA TTYIVSRLKP FTSYQFRIKA TNDIGDSEYS
QESEAITTLQ DVPDEAPSIL SVTPYTTTSV LIRWQPPSEE KINGILLGFR IRYRELLYDR
LRSYIHTVNS ASAWAELSAP YSLRNLSDST LTQYELDKLS KHKRYEIRMS VYNAVGEGPT
SPPQEVFVGE AVPTAPPQNV AIQSATATQL DVTWDPPPVD AQNGDIQGYK IYFWEFQRKN
ETERMRTLFM PEGGVKLKNL TGYTTYMISV APFNAAGDGP RSPPTRGRTQ QAAPSAPSFI
HFSELTTTSV NVSWGEPTFP NGIIEGYRLV YEPSTPVDES SVACADCLHS PSPPGVSKTV
TVDVKGTGPL WLKIRDLADG VTYNFRIRAK TFIYGPEVEA NITTGPGEGA PGPPGEPFIT
RYSSGLTIHW TPGDPGRSPI TRYVIEARPS DEGLWDILIK DISKDATSHT FNMDILKQGV
SYDFRVIGVN DYGYGSPSLP SPSISAQKVA PFYEEWWFLV VVALVGLIFI LLLVFILIIR
GQSKKYAKKS ESGNNSNCNA LTHGDMVSLD EGRFPALELN NRRLSVKNSF CRKNGVYTRS
PPRPSPGSLH YSDEDVSTKY NDLIPAESSS LTEKPSEISD SQGSDSEYEV DPNRQKTHSF
VNHYISDPTY YNSWRRQQKG ISRAQAYSYT ESESGEPDHC APPPLPPLPP LPPQLSSPSP
QPQQAQGQPQ GQGSLFRPKG SRTPTPSQQS SNPPSQHSTL YRPPSSLAPG SRAPIAGFSS
FV
//
