ID A0A3P9BBG8_9CICH Unreviewed; 745 AA.
AC A0A3P9BBG8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Protein LDOC1 {ECO:0000256|ARBA:ARBA00044088};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005007240.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005007240.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005007240.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: May have an important role in the development and/or
CC progression of some cancers. {ECO:0000256|ARBA:ARBA00043935}.
CC -!- SUBUNIT: Interacts with NOD2. {ECO:0000256|ARBA:ARBA00044034}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the LDOC1 family.
CC {ECO:0000256|ARBA:ARBA00043960}.
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DR AlphaFoldDB; A0A3P9BBG8; -.
DR STRING; 106582.ENSMZEP00005007240; -.
DR Ensembl; ENSMZET00005007550.1; ENSMZEP00005007240.1; ENSMZEG00005005578.1.
DR GeneTree; ENSGT00940000171189; -.
DR Proteomes; UP000265160; LG15.
DR CDD; cd00303; retropepsin_like; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR032549; DUF4939.
DR InterPro; IPR032567; LDOC1-rel.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR15503:SF22; CCHC-TYPE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR15503; LDOC1 RELATED; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF16297; DUF4939; 1.
DR Pfam; PF08284; RVP_2; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 683..741
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 75..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 745 AA; 82542 MW; F0188BBA115D65D0 CRC64;
MDSADSTPLQ REIALQAERL ERHETMLQHV AKEQSALLQV VSELKGMLLA TPRAPVQPQG
GPAQPQPPIA LLDEAAASPL PPSPPPPRRE HALPVPEKFG GDLDKCRGFL IQCSLMFRQQ
TQAYASDITK ITFMVELLTG RALQWAQAVL SAQPSISYSN FLSKFRCVFD KGSNPDSAAH
RLFALKQGRR TVADFSVDFW ILSEELASKE LPKSLSALVN LCISLDDHMR EFGRRSGDGR
RSAGGVGIPS LEWREEEPDS PADEEQPMQL GRTRFNRRRR RLVGECFECG KRGHFADALK
VGILTGAPAS SVLHLSCPAK LQFLSCIHPC NVLIDSGAEQ SFVDEALAFK IGLPVVPLPE
TLEVSALNGS TLASVSHRTQ EITLTLSGNH TERIRLFLLK APHTPLVLGF PWLQQHNPHI
DWARGCITGW STYCHEQCLR SAVPVCVTTD PAGLPAPPDL SSVPADYHDL SQVFSKDRAQ
SLPPHRPYDC GIDLLPGAPL PSSRLYNIAK PERESMERYI TDSLAVGIIR PSTSPLGAGF
FFVEKKDKTL RPCIDFRGLN KITVKNKYPL PLLVSAFELL QGATLADRRR VPAPAYRVGQ
QVWLSSRTIP LRTESKKLSP RFLGPFSVQA VLNPVTVRLA LPRNMKVHNV FHVSQLRPVR
TSPLCPPPEP PLPARMVAGA PAYDITRIMD ARRRGRGFQF LVDWAGYGPE ERSWVPRSAI
LDHGMVREFR RRHPDKFRGS PGGSR
//
