ID A0A3P9BCE5_9CICH Unreviewed; 539 AA.
AC A0A3P9BCE5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Galectin-3-binding protein B {ECO:0000313|Ensembl:ENSMZEP00005007580.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005007580.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005007580.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005007580.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR AlphaFoldDB; A0A3P9BCE5; -.
DR Ensembl; ENSMZET00005007896.1; ENSMZEP00005007580.1; ENSMZEG00005005768.1.
DR GeneTree; ENSGT00940000164412; -.
DR Proteomes; UP000265160; LG23.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd18496; BACK_LGALS3BP; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 3.10.250.10; SRCR-like domain; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR24410:SF16; GALECTIN-3-BINDING PROTEIN; 1.
DR PANTHER; PTHR24410; HL07962P-RELATED; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00530; SRCR; 1.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00202; SR; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF56487; SRCR-like; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS50287; SRCR_2; 1.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT DOMAIN 10..110
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 143..210
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DISULFID 35..99
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 48..109
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 79..89
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 539 AA; 60529 MW; C75E3FF7257A4374 CRC64;
FNCEIVSSPK RLAGGQEYSE GRVEIFHDGV WGTICDDGWD INDAHVVCRQ LRFPGAAEAP
GSAAFGAGVG NIWMDDLTCG GSEINLLQCT FPGWGVHNCG HGEDAGVRCE KGEDVSIRTE
YTLDHNASLS QQLGELFDSR QDCDVDIAVA VDNNIVETIC AHRVILSLNS NLKSLHPDLS
SLLINVSSDC SQHADIFVRY FYTRKITVTL ASSHCILKMA SDWGLTEYHN EAANLFRLFL
PEDPTFQSQN SLYEYAVRRS DDTLQQLCLR YLAWNCEALI NSPAWTSLPF NLVKALLSRS
DLVVRNETVV LSGLERWAEA RGNATMREIL LNLVRFPMIP AEDLYSLDSS EYHASKLEGF
QFNALPVKML LSDLTGTIYT PRIYTGRPWS FTFSSQEIRA YQHSGVYILR GQRVSSLTSD
FQTPVHNSAY FAFHTMRWKV TTYVREEDCT KQSVTCASLP AISLKIEQKN LPSEMEGRIR
YSNRLILMCA GRHVFHVNEF NAVDSDSPIA VPSISEQVYP CHSNLFSYQV VVRPQYSTD
//
