ID A0A3P9BEP0_9CICH Unreviewed; 1672 AA.
AC A0A3P9BEP0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Neurexin-3b {ECO:0000313|Ensembl:ENSMZEP00005008358.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005008358.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005008358.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005008358.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSMZET00005008691.1; ENSMZEP00005008358.1; ENSMZEG00005006317.1.
DR GeneTree; ENSGT00940000167343; -.
DR Proteomes; UP000265160; LG15.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00110; LamG; 6.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR15036:SF48; NEUREXIN-3B; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF02210; Laminin_G_2; 6.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00282; LamG; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1672
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018100457"
FT TRANSMEM 1595..1615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..203
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 194..231
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 238..420
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 427..619
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 623..660
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 665..837
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 851..1026
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1029..1066
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1070..1270
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1302..1324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1398..1445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1482..1534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1636..1672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1410..1427
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1501..1515
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1672 AA; 183431 MW; 396153D8303B038A CRC64;
MNPNSLPGFF LMLLSTMLGL SIGLEFTGSE GQWARYLRWD ASTRSDMTFQ FKTSEPEGLM
LYFDDGGYCD FLLLAVSEGK LQLRVSIDCA ETTITSDKMV NDSRWHFAAI NRHNLRTGLA
LDGQTKTEEV RPQRQFMNIV SDLFLGGLPG DIRTSAITLP SVRELAPFKG IITDLSYGSK
LPTLINSQKV RLEMMGLCTE NPCENGGICS LADGEPYCDC SRTGYVGRYC TEAREENVAT
FRGSEYFCYD LSQNPIQSSS DEITLSFKTW QRNGLLLHTG KSADYVNLAL KDGAVSLVIN
LGSGAFEAIV EPVNGKFNDN SWHDIKVTRN LRQVTISVDG ILTTTGYTQE DYTMLGSDDF
FYVGGSPSTA DLPGSPVSNN FMGCLKEVVY KNNDIRLELS RLARIVDPKM KLQGDVVFKC
ENVPTLDPIN FETPESYLAL PKWNTKRVGS ISFDFRTSEP NGLILFTHGK PQDRRDAKGQ
KNNKVDFFAV ELLDGGLYLL LDMGSGTIKV KATQAKVNDG SWHHVDIQRD GRSGIISVNS
RRTPFTASGE NEILDLEGDL YLGGLPDSRM GLVLPTELWT AMLNYGYVGC VRDLFIDGRS
KDIRQIAQSQ NMTGIKSSCS KVTGKQCDSN PCKNNGVCKE GWNRFICDCT GTGFWDSTCE
REASILSYDG SMYMKVVIPN IIHTEAEDVS LRFMSQRAFG LLMAATSRES ADTLRLELDS
GRVKLTVNLD CVRINCNTSK GPEVLYAGQK LNDNEWHSVR VVRRGKNFKL TVDDDMAEGQ
MAGDHTRLEF NNVETGILTE RRFVSSAPSP FIGHLQSLKF NGMQYIDMCK NGDIDFCELN
ARFGMRFIIA DPVTFKTKGS YLGLATLQAY TTMHLFFQFK TTSPDGFIIF NSGDGNDFIA
VELVKGFIHY VFDLGNGPSL LKGNSDNPLN DNQWHNVVIT RDASNTHTLK VDAKSVTQNV
NGAKNLDLKG DLFIGGLGPN MYQNLPKLVV SREGFQGCLA SVDLNGRLPD LISDALFRSG
QIERGCEGPS TTCQEDSCAN MGVCIQHWEN FTCDCSLTSY SGTYCNDPGT TYIFGKGGGL
ITYTWPNNER PSTRTDRLAV GFSTTIKDGI LVRIDSAPRL GDYIMLHIEQ GKIGVTFNIG
TVDISVKEVN TLINDGKYHL VRFTRNGGNA TLQVDNWPVN EHFPTGNSDI ERYQMANKKI
PFKYTRPVED WLQDKGRQLT IFNTQATISI GGNDRKRPYQ GQLSGLYYNG LKVLNMAAEG
HINIKVNGSV RLVGDVPTSR GAARTTTSVP PEMSTTFIET TTTLSTTTTR KQRSPPTIQT
TDDIVSSAEC SSDDEDLEEC DSGHAGGELV IPVLVEDPID IPSVSTRSPF IPLPPTLRPV
LTIIETTKES LAMATEAGVP CLSDRGSDDC DDGDGGDDGD DDDDDGMVIS GFGSGEAFDS
SLPPTDDEDF YTTFSLVTDK ILTTSAYEGS YKALAPKWEA KDLRPSKASE AGRTAPTSPL
PDLRGTPPAA VPSDTPPKLP AGKMNNREVK PPQPDMVLVS LPTSFDLDGT KPRGPFITSP
MLRTVPAALP TVPGVQRVPP GASEVVRESS STTGMVVGIV SAAALCILIL LYAMYKYRNR
EEGSYQVDET RNYISNSAQT NGAVVKDKAP SGSAKGSASS KRPKDKDKEY YV
//
