ID A0A3P9BGI1_9CICH Unreviewed; 609 AA.
AC A0A3P9BGI1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Histidine ammonia-lyase {ECO:0000313|Ensembl:ENSMZEP00005008851.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005008851.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005008851.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005008851.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PAL/histidase family.
CC {ECO:0000256|ARBA:ARBA00007238}.
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DR AlphaFoldDB; A0A3P9BGI1; -.
DR Ensembl; ENSMZET00005009194.1; ENSMZEP00005008851.1; ENSMZEG00005006684.1.
DR GeneTree; ENSGT00390000009047; -.
DR Proteomes; UP000265160; LG7.
DR GO; GO:0016841; F:ammonia-lyase activity; IEA:InterPro.
DR CDD; cd00332; PAL-HAL; 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 2.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR001106; Aromatic_Lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR022313; Phe/His_NH3-lyase_AS.
DR PANTHER; PTHR10362; HISTIDINE AMMONIA-LYASE; 1.
DR PANTHER; PTHR10362:SF7; HISTIDINE AMMONIA-LYASE; 1.
DR Pfam; PF00221; Lyase_aromatic; 2.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00488; PAL_HISTIDASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 5..79
FT /note="Par3/HAL N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12053"
FT REGION 587..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 66831 MW; DE429596D25A6D0C CRC64;
MPRFTVHIRD EWLAVPCRDT SKTIQWLGQE ALKRYIKNKP DNGGITAVKD TRFVVRRCQG
LGLLDADDTI EDVLEDNDFV ELAIEGDTMS PDFIPCEPGY ISLDGNSLTS TDLINLGRGL
YKIKLTPEAE RKVVQSRELL DTIVKENKVV YGITTGFGKF ARTVIPVSKL KELQENLVRS
HSAGVGNPLS PERTRMLLAL RINVLAKGHS GVSLETLQAM IQAFNASCLS FVPEKGTVGA
SGDLAPLSHL ALGLMGEGKM WSPTSGWADA KYVLEAHGLK PISLKPKEGL ALINGTQMIT
SLGAEAVERA QAIAQQADII AALTLEVLKG TTKAFDSESH RFCDRVQDAY TMRCCPQVHG
IANDTIAFVQ NIINTEINSA TDNPMVFAER GETISGGNFH GEYPAKALDF LAIAVHELAS
ISERRIERLC NPSLSELPAF LVNEGGLNSG FMIAHCTAAA LVSENKVLCH PSSVDSLSTS
AATEDHVSMG GWAARKALRV IEHVEQVLAI ELLAACQGIE FLRPLRTTTP LEKVYELVRS
VVKPWIKDRF MSPDIEAVHR LLLDQKVWNV AKPYIEKYQT EYIPESRPVS PTAFSLDSPA
SPRKRVRHE
//
