ID A0A3P9BH45_9CICH Unreviewed; 494 AA.
AC A0A3P9BH45;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Cyclic AMP-responsive element-binding protein 3-like protein 3 {ECO:0000313|Ensembl:ENSMZEP00005009244.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005009244.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005009244.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005009244.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the bZIP family. ATF subfamily.
CC {ECO:0000256|ARBA:ARBA00009050}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004547225.1; XM_004547168.3.
DR AlphaFoldDB; A0A3P9BH45; -.
DR STRING; 106582.ENSMZEP00005009244; -.
DR Ensembl; ENSMZET00005009594.1; ENSMZEP00005009244.1; ENSMZEG00005007017.1.
DR GeneID; 101486384; -.
DR KEGG; mze:101486384; -.
DR CTD; 406853; -.
DR GeneTree; ENSGT00940000160343; -.
DR OrthoDB; 5362396at2759; -.
DR Proteomes; UP000265160; LG12.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd14689; bZIP_CREB3; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR PANTHER; PTHR45996; AGAP001464-PB; 1.
DR PANTHER; PTHR45996:SF4; CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 251..314
FT /note="BZIP"
FT /evidence="ECO:0000259|PROSITE:PS50217"
FT REGION 64..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 290..317
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 422..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 494 AA; 53906 MW; C708FD8B05D56FC5 CRC64;
MSIAEDLPDM DGADLFGLLF HDGENGSTEP FFPDGNGLIE SWLSEQDMLP DMDTEDFLSS
LLDGEDNTET ISPSHSPLGS DSGISDDSSS GAGNNNHVGC PSPHSSDSDV VPSPSYSQPS
PVHSDLAVTY SEAQTESFEA LTVQADHSYS LLQSGGRDMD VLQSVRAEKP DTDVFIDLDD
LVTEAMEEDV SSELPCTLAI EDSVQDTTES IKEDQFQFKE IVLTEEEKRL LAKEGVTIPQ
HMPLTKAEER TLKRIRRKIR NKQSAQESRK KKKVYVDGLE NRVAICTAHN LELQKKVQML
QKQNMSLIEQ LRKLQAIVKM STMKASTTST CVMVFLLSFC LIIFPSVNPF GGNTQTKELY
TPSSIVSRSL RSLPAESTDA VSSSEAKEGL LVHQVEVDNV KAIFAGGQKN HTPDYERVEQ
PDSETGVNSN SSADFPSPAQ AAEMKQGPAG ALQEGSINGV VASAVAYNAK ASKDAWIDRN
PPSVILQQHR SDEM
//
