ID A0A3P9BH61_9CICH Unreviewed; 1070 AA.
AC A0A3P9BH61;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Ras association (RalGDS/AF-6) and pleckstrin homology domains 1b {ECO:0000313|Ensembl:ENSMZEP00005009232.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005009232.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005009232.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005009232.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P9BH61; -.
DR Ensembl; ENSMZET00005009582.1; ENSMZEP00005009232.1; ENSMZEG00005005956.1.
DR GeneTree; ENSGT00940000156552; -.
DR Proteomes; UP000265160; LG23.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR PANTHER; PTHR11243:SF15; RAS-ASSOCIATED AND PLECKSTRIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 322..399
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 429..540
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..1033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..665
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..742
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..784
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..886
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..951
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..997
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1070 AA; 116576 MW; A10D5C545993D23D CRC64;
MDQVSDDELD HGAEEDSDKE DQDLDKMFGA WLGELDKLTQ SLDDGRPQKA LQKPPLRQET
NMANFSYRFS MYNINEALNQ GDTVDLDALM ADLCSIEQEL NTISKPNSTS RSQSKGQQRA
AGGRSASTKH TGTSGSATAR PAASNISLDD ITSQLEKASL SMDEAARQTS SSSSSSSSFS
SRQHRRTGSV GAVTEQDAPS QRSSVNSACA SASSMDSLDT DKVTGGEVES QGSPISQGQN
QTNTEHVTLR RANSKPARRQ LDFTSREGEV DRHSYLDQET SLILKSIAGK PSHLLTKEEQ
AAKLKAEKIR VALEKIKEAQ VKKLVIRVHM SDESSKTMMV DERQTSHCGY SPDWSLVETI
TELQMERIFE DHENLVENLL NWTRDSHNKL MFIERETFSP SHPSTDFTVL LNCFQNYLLG
RKETSEMADR NKEALLEECF CGGSVSSWKK RYFLLRASGI YYVPKGKAKA SRDLVCFLQL
DHVNVYYGQD YRSKYKAPTD YCLALKHPQI QKKSQYIKYL CCDDVRTLHQ WVNGIRIAKY
GKQLYLNYQE AMKRTEAAYD WSSLSTSSIR SGSSSASIPE SQSNHSGHSD SGVDTGSSHG
RSQSVVSSIF SEAWKRGTQI EENSKAFSNY NHMPPQEQQQ PAPAPPPPPP PPPPPPPPPP
PVQTVSYQSP ALTMYKYSTI TRLQNQKEAR YLFTSLLQPS SQPVYHSGLK QALKERFPSP
PRDLPSPNGG LEYSPPPAPT HHPASSTSAT AATTSSSSTV PSTGPVSTSS CTPGSTTEKT
SPRLSPSYCP KPMSPGLPFP PAPPPATMSC PTPAPHHPLL YLHPLRSICL SHQPFHRSPS
HHVSGETASQ SVPRSFIPSR QSNGGFEAPL SPLQLKPNQN GSVGVATAAV SRIPPSSPDS
NTASLTSSHP PEELQHQVQR NTAPPSSCPP SNGSPSKEPS NGPPAPPKPG KLNLANLPLA
LQAKCAYFPP PPPVMTPYGR PLEPPPLSPP PPTSPKAKVS GTPGLHQLRR ASQAVGPRGT
MDDMALPPNG GNGGYMSGNI SGYATLRRGP PPAHPKEGMV CFYIKLFKDW
//