ID A0A3P9BHA6_9CICH Unreviewed; 821 AA.
AC A0A3P9BHA6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Colony stimulating factor 3 receptor {ECO:0000313|Ensembl:ENSMZEP00005009282.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005009282.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005009282.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005009282.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_004551039.1; XM_004550982.2.
DR AlphaFoldDB; A0A3P9BHA6; -.
DR STRING; 106582.ENSMZEP00005009282; -.
DR Ensembl; ENSMZET00005009632.1; ENSMZEP00005009282.1; ENSMZEG00005007036.1.
DR GeneID; 101478204; -.
DR CTD; 1441; -.
DR GeneTree; ENSGT00940000158915; -.
DR OrthoDB; 5354422at2759; -.
DR Proteomes; UP000265160; LG11.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0140313; F:molecular sequestering activity; IEA:Ensembl.
DR GO; GO:0060216; P:definitive hemopoiesis; IEA:Ensembl.
DR GO; GO:0035162; P:embryonic hemopoiesis; IEA:Ensembl.
DR GO; GO:0030225; P:macrophage differentiation; IEA:Ensembl.
DR GO; GO:0030224; P:monocyte differentiation; IEA:Ensembl.
DR GO; GO:0030223; P:neutrophil differentiation; IEA:Ensembl.
DR GO; GO:1901534; P:positive regulation of hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010457; IgC2-like_lig-bd.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF103; GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR; 1.
DR Pfam; PF06328; Lep_receptor_Ig; 1.
DR SMART; SM00060; FN3; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..821
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018268661"
FT TRANSMEM 607..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..142
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 224..322
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 821 AA; 92202 MW; 61170447C57A1FC5 CRC64;
MISKWMSVIV MLVTFVNGAR NEDGIQPCAK VHTSSSVVPL GSPVTATCVI REDCPLVTGQ
AVHIEWRLDD RLIPSSPEAS ESSRVSRAVI SSFNHTRAIL TCCIQASPPQ VVAGVEIRAG
YPPEAPQNLT CQTNLTNPIT ITCSWDPGQR ETHLPTQYSL HTEMWAENEN YSYKLPQGVH
HYTIPRFEFV LFYDMKIYVK AVNELGETTS APLVLEPVSS AKFDPPSIQV ISKRYGCLRL
NWNLSPDQAW LQSCGLLNLE YRFKSVDSTQ WNDPVLVQNA KTPVDMCHLL HWTRYFAQIR
VRYQQSPWSE WSSSQSGVTL ESAPTGRLDS WMEISEDPLL KQLNISLFWK PSKRFRANGQ
NVSYIVLVQK RVVCSTRENY CTFSLSRSVK KVYVKAVNAA GKSSPTVVQI YKHKAHPVVL
DATAVPYGNN SFLVQWRSMD SSGLSDYVVK WRPLLKSGLS HIQFDIAGQN QSSIVITGSF
EPYKPYGISV YPRFMDGIGP PKTFNAYLRE KAPSMVPKLH IQKTWNSDIK ITWDEIPLDQ
RNGKIQDYTV FYWNQKGPVN VVNVDTEKRS VILKDPSVHG AVLMVSTFGG SLNGSAVHFE
FQPFDEVASA MIVIGSVFGL SLLIIFIVLT CFSKHERFKG IFWPVVPDPA NSFVLRLTSE
STQYTHPSCD SEDPIYLSHL SFPDIPMKLS KEEDDLWINS SEETSDLGES ICGSPFITEY
SGSNSDSVPY ATVVFSGFCN SPPPKEPHVY LRSESTQPLL EAEEPFTPKC YQNLALGGMT
EEQHFFGPSH DCVPEEVADP ESLWDDFPFL RALAMNDTEN D
//
