ID A0A3P9BHS2_9CICH Unreviewed; 1132 AA.
AC A0A3P9BHS2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=IQ motif and SEC7 domain-containing protein 1 {ECO:0000313|Ensembl:ENSMZEP00005009286.1};
GN Name=IQSEC1 {ECO:0000313|Ensembl:ENSMZEP00005009286.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005009286.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005009286.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005009286.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
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DR RefSeq; XP_004559927.1; XM_004559870.2.
DR AlphaFoldDB; A0A3P9BHS2; -.
DR Ensembl; ENSMZET00005009636.1; ENSMZEP00005009286.1; ENSMZEG00005006907.1.
DR GeneID; 101485759; -.
DR CTD; 100148736; -.
DR GeneTree; ENSGT00940000156915; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000265160; LG5.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF327; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 516..709
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 312..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 921..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1026..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..497
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..896
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..1009
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1062..1077
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1132 AA; 127455 MW; 87353364407FEA49 CRC64;
MWCLQCASDR TQSLLELESY SCVEGDAPGT EVGASVDPSG GYSCVPVTHS GGLGPDHLDS
QLYGHILLPG HPRPRRPKLQ HSQSILRKQA EEEAIKRSRS LSESYELSSD LQDKQVEMLE
RKYGGRFITR HAARTIQTAF RQYQMNKNFE RLRSSMSENR MSRRIVLSNM RMQFSFEGPE
KVHSSYFEGK QVSLTDDGTK IGALRQSDHG GEMGVQAKTP TTQSDFTDAI TELEDAFSRQ
VKSLAESIDD ALNCRSLHGE DSQSEPGRGL QDMDREVTCQ VKPSHSASEH RKLDEMTASY
SDVTLYIDEE ELSPPLPLSQ SVDRPSSTES DLRQRSLNSS QDYWSLAHKD EKGDTDTSCR
STPSLECQEQ RLRVDHLPLL TIEPPSDSSV ELSDRSDRSS LKRQNAYERS ISNQQSSPKQ
VSHSLPPRGP SREEDTSRHR SRQLEAHLAI NGTANRQSKS ESDFSDGDND SINSTSNSND
TINCSSESSS RDSLREQTLS KQTYHKETRN SWDSPAFSND IIRKRHYRIG LNLFNKKPEK
GIQYLIERNF VPDTPVGVAH FLLQRKGLSR QMIGEFLGNR QKQFNRDVLD CVVDEMDFSA
MELDEALRKF QAHIRVQGEA QKVERLIEAF SQRYCICNPG VVRQFRNPDT IFILAFAIIL
LNTDMYSPNV KPERKMKLED FVKNLRGVDD GEDIPREMLV GIYERIRKRE LKTNEDHVSQ
VQKVEKLIVG KKPIGSLHHG LGCVLSLPHR RLVCYCRLFE VPDPNKPQKL GLHQREIFLF
NDLLVVTKIF QKKKNSVTYS FRQSFSLYGM QVLLFENQYY PNGVRLTSAI PGADIKVLIN
FNAPNPQDRK KFTDDLRESI AEVQEMEKYR IESELEKQKG VVRPSMSQSS GLKKDAGNGN
LSRASLDDSY AIGEGLKRSA LSSSLRDLSD AGKRGRRSSA GSLDSNMEGS IISSPHMRRR
APSSRDCPSR HSAQSLPNSS SLLGSLFGTR RVKSPSPTPQ PQLHPTLISH TPHPANLHHT
ARVETEGPVP MHPHHAQFCH MTQNPPPYHH HHHYHPPAHL QHPPHQYHPP PSHSQQQPYP
AHPHGPHGHG SHPPHSSTHP THGPPHHHGA PPPSSQGPSS TKPKHSGIST VV
//
