ID A0A3P9BHX3_9CICH Unreviewed; 1234 AA.
AC A0A3P9BHX3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Ras association (RalGDS/AF-6) and pleckstrin homology domains 1b {ECO:0000313|Ensembl:ENSMZEP00005009497.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005009497.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005009497.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005009497.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9BHX3; -.
DR STRING; 106582.ENSMZEP00005009497; -.
DR Ensembl; ENSMZET00005009855.1; ENSMZEP00005009497.1; ENSMZEG00005005956.1.
DR GeneTree; ENSGT00940000156552; -.
DR Proteomes; UP000265160; LG23.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR PANTHER; PTHR11243:SF15; RAS-ASSOCIATED AND PLECKSTRIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 361..438
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 468..579
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..1029
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1063
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1074..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1215..1234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..703
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..731
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..825
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..867
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..972
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1029
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1074..1088
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1097..1114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1146..1173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1234 AA; 133931 MW; 683A20C517C2B485 CRC64;
MDQVSDDELD HGAEEDSDKE DQDLDKMFGA WLGELDKLTQ SLDDGRPQKA LQKPPLRQET
NMANFSYRFS MYNINEALNQ GDTVDLDALM ADLCSIEQEL NTISKPNSTS RSQSKGQQRA
AGGRSASTKH TGTSGGGSSG GSASSSTRAS PANTVQGGSA TARPAASNIS LDDITSQLEK
ASLSMDEAAR QTSSSSSSSS SFSSSTIRRP SSGSSGGGGQ HRRTGSVGAV TEQDAPSQRS
SVNSACASAS SMDSLDTDKV TGGEVESQGS PISQGQNQTN TEHVTLRRAN SKPARRQLDF
TSREGEVDRA THSYLDQETS LILKSIAGKP SHLLTKEEQA AKLKAEKIRV ALEKIKEAQV
KKLVIRVHMS DESSKTMMVD ERQTSHCGYS PDWSLVETIT ELQMERIFED HENLVENLLN
WTRDSHNKLM FIERETFSPS HPSTDFTVLL NCFQNYLLGR KETSEMADRN KEALLEECFC
GGSVSSWKKR YFLLRASGIY YVPKGKAKAS RDLVCFLQLD HVNVYYGQDY RSKYKAPTDY
CLALKHPQIQ KKSQYIKYLC CDDVRTLHQW VNGIRIAKYG KQLYLNYQEA MKRTEAAYDW
SSLSTSSIRS GSSSASIPES QSNHSGHSDS GVDTGSSHGR SQSVVSSIFS EAWKRGTQIE
ENSKAAPPPP LQPPQSAQLH QQQLQKQQQS QAFSNYNHMP PQEQQQPAPA PPPPPPPPPP
PPPPPPPVQT VSYQSPALTM YKYSTITRLQ NQKEARYLFT SLLQPSRPSN QRQSHCPIAA
APVSQPVYHS GLKQALKERF PSPPRDLPSP NGGLEYSPPP APTHHPASST SATAATTSSS
STVPSTGPVS TSSCTPGSTT EKTSPRLSPS YCPKPMSPGL PFPPAPPPAT MSCPTPAPHH
PLLYLHPLRS SSASRQPHLP QPLQLCLSSI VCLSHQPFHR SPSHHVSGET ASQSVPRSFI
PSRQSNGAWG WPQLQSPEFP PPLQTATPLP CSTTTTSSPP PLPSTSHRSD FWRQEPPPTP
QRNSSIKSNA STLRGIQENL LSSLLPKEPS NGPPAPPKPG KLNLANLPLA LQAKVSQAKQ
SGGDFPSPPL SAPTSHLLHL PPSSSPLHTS SGESPAPGSP PPPPISSSVT QHGERTPEKD
SSAHARRVVT TPQTTSALAT STDFPKGSSG QPNFLEDLNR TLRRKSVGPA PGPRKAKQRR
KRWLYVRKHL RLCNTTTRTP SCPPKRGDGT KLTG
//
