ID A0A3P9BI15_9CICH Unreviewed; 1240 AA.
AC A0A3P9BI15;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Rho guanine nucleotide exchange factor 9 {ECO:0000256|ARBA:ARBA00017486};
DE AltName: Full=Collybistin {ECO:0000256|ARBA:ARBA00031572};
DE AltName: Full=Rac/Cdc42 guanine nucleotide exchange factor 9 {ECO:0000256|ARBA:ARBA00032237};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005009537.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005009537.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005009537.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for CDC42.
CC Promotes formation of GPHN clusters. {ECO:0000256|ARBA:ARBA00043844}.
CC -!- SUBUNIT: Interacts with GPHN. {ECO:0000256|ARBA:ARBA00011232}.
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DR AlphaFoldDB; A0A3P9BI15; -.
DR STRING; 106582.ENSMZEP00005009537; -.
DR Ensembl; ENSMZET00005009896.1; ENSMZEP00005009537.1; ENSMZEG00005007201.1.
DR GeneTree; ENSGT00940000154103; -.
DR Proteomes; UP000265160; LG2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11975; SH3_ARHGEF9; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035728; ARHGEF9_SH3.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47544; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR PANTHER; PTHR47544:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 733..792
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 831..1015
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1046..1153
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 33..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 696..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..480
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1240 AA; 139895 MW; 55E262F4564D8F76 CRC64;
MEQTGNPALE SNNPNGFVNR VFNVSLDVEN ETSSVYIQET GTGPAEGQGE TQAASSQTPV
KDRQEVNRRP RATGGIWRIL NRKRAVSELE RRPHSMILPG EASIPKLSFA DKVRSFKKLK
SPAVFRGKAG KLSTAKFTSS LVDEESFCRD IGTPQQPSGG TLRQRGQRHS YAGYTAQFDC
LFEDIDLSTS MDGHQSTITG EAVTQNGCKP SEKVSYTKRS HNNSANCNKT AAACEELSTR
DSPRTHRSGG RRHKDVWSYL RRISLLGKTN PVYSERSFDS ELPSLDKTID SDYGSVDFES
VRDFQPPPPK QSDTKGHFGG LFKFFNNFAE TARRWRTTSR SFSPPEGEKT PMSSPRAPQR
AVDNVHSVSL TLHNEGLPTS QPTPSSPVTS KFLHSNSFNG DTPAPVTGGR SPPVVLKAFR
PCSGPQAVNG LQSFEVTDKP ADRETNLRSK AIVENHVPHL GLNTEAESEA EVERDQSDSL
CQEENVAGQT GNEQDSQDAP LDSHQIQEVN VQSQQGDKES TTNSVPASDS TEEIFKLCEQ
IASQTGCSVR QPGPALPHSS TEKTSVPQKR LRPRPRPASA VLDLWRPNPD RDLDSHYSEV
GSLSRRRRRP ATTVQHSLGQ RGMTSRARPC SVIETSVTRE TQSTELHHRA LSRPPGVSPL
EPPHRASLQR CRSLPLPPST LTALALLLPQ SADMGQSSSS VRLRSGGSGS CRRRRLLRPG
SEPLQVNILI SGGSIVNAEA VWDHVTMADR ELAFKAGDVI KVLDASNKDW WWGQIDEEEG
WFPASFVRLW VNQEDGGAEP AEGTSEVQNG HLDPTNDCLC LGSPLQNRDQ MRANVINEIM
STERHYIKHL KDICEGYLRQ CRKRVDMFND DQLKVIFGNI EDIYRFQMGF VRDLEKQYNT
EEPHLSEIGP CFLEHQDGFW IYSEYCNNHL DACMELSKLM RDGRYQHFFE ACRLLQQMID
IAIDGFLLTP VQKICKYPLQ LAELLKYTAQ EHSDYRYVAA ALAVMRNVTQ QINERKRRLE
NIDKIAQWQA SVLDWEGDDI LDRSSELIYT GELSWIYQPY GRSQQRVFFL FDHQLVLCKK
DLIRRDILYY KGRIDMDRYE VRDTIDGRDE DFNVSVKNAF KLCNKDSEEI HIFLAKKPEE
KIRWLRAFAE ERKMVQEDEK IGFEISEYQK RQAAMTVRKV TKQKGEATRR YQVISLFFFS
SLVCSVFSSL FTLPFTCSVF LLSTPFLTHT LFMDGPRLAL
//