ID A0A3P9BIZ6_9CICH Unreviewed; 1141 AA.
AC A0A3P9BIZ6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Bromodomain adjacent to zinc finger domain 2B {ECO:0000313|Ensembl:ENSMZEP00005009858.1};
GN Name=BAZ2B {ECO:0000313|Ensembl:ENSMZEP00005009858.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005009858.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005009858.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005009858.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P9BIZ6; -.
DR STRING; 106582.ENSMZEP00005009858; -.
DR Ensembl; ENSMZET00005010220.1; ENSMZEP00005009858.1; ENSMZEG00005007380.1.
DR GeneTree; ENSGT00940000155359; -.
DR Proteomes; UP000265160; LG16.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR CDD; cd01397; HAT_MBD; 1.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR PANTHER; PTHR45915:SF8; BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B-LIKE ISOFORM X1; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 541..612
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 884..949
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT REGION 147..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 645..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1083..1141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 714..748
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 831..858
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 153..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..262
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..441
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1094..1116
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1117..1131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1141 AA; 127072 MW; DCF0BE8AA3636E0D CRC64;
MESGRPLASS PEPFFLHMAS SKASSSPAPP QKLHTNRFSD SYNCLLCSPG HSLRIMEDEC
VNMSVSPNGL NLANSPVALN ASSSSCSEFG GLGCLGLSAL AAPSQLGTFP DWWRTSETQT
RAAAAFFPPL LGLHPFVLST FKSHDPVDFQ SRPSGKRSLS LGVNGTVNGR SASSPAGNAP
AMNTSSLLAK GKKETPQANS HEPGQLHQKA VEKKPNKRPL ETSSMSGSQS ESQSESSSEV
EESSSDPDDM EEEDDDDQSS DSEESGYEKQ SPAKQKVKVS ASLELLCKQR VYRISELFSL
HISSSNMFLN LYPNGAINGA VQDAPLALIT KPRIQSSTPN SKPLLAATSP PCSMPINLST
GTKEMLDSSA SPLKTSASSE PRSRKTTQTV HSGRSLTRTN TSCLPVDLVR GSEPDIHSSK
NSDDSLGDDY DEDEDEDSGS SFSESESILG SDSDAFEDDV KESVETEADS DAERSPLKLA
QTSLSTQKSS SSLSATPSLL NIQITKPPSL HSSFFMTIYL HSCEQQGHRL HCEHQFYINY
VLLGVFLFCF FPFRWQRETR IRTVAGRLQG EVAYFAPCGK KLRQYPDVVK YLIRNGITEI
SRDNFSFSTK IKVGDFYEAR EGPEGIQWFL LAEDEIAPSI IAMDGRRSRR TKSEHQPTGD
STGAIQWKPY PLNGGENNFQ DVSDAKLLRK LEAQEIARQA AQIKMMRKLE KQAIAQAAKE
AKKQQAIMAA EERRKKREQL KILKQQEKIK RIQQIRMEKE LRAQQILEVC PESYCRNILK
HFLSAVDRIY RKKKKSNQRL FLNYVERERR RQHMILMKAV EARKKAEVRR MSETRKLNKE
RKLELRRLEL EKAKELKKPN EDMCLADHKP LPELSRIPGL VLAGSTFSNC LMVLQFLHSF
GKVLGLDLNS DPLTIGDLQE GLLNIAENME KVQDLLVTML SAAVCDPGVP AGHKSKTILG
DNLTNVEINR DNVSEILQIY MEGHSEQKEV AMLAFSLRTK PFQAHSPSQK ASVLAFLVNE
LCCSKVVISE IDKNIDYMTN LRKDKWVVEG KLRKLRSIHT KKTGKKDNSW AGENNHAFVL
VSVQNKSKRK EGDSEEEEDE DDDSEDQRDD EEEEEEEAGG KRGKKTDICE EEVSGNIMLL
T
//
