ID A0A3P9BJ37_9CICH Unreviewed; 969 AA.
AC A0A3P9BJ37;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Bromodomain adjacent to zinc finger domain 2B {ECO:0000313|Ensembl:ENSMZEP00005009898.1};
GN Name=BAZ2B {ECO:0000313|Ensembl:ENSMZEP00005009898.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005009898.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005009898.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005009898.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9BJ37; -.
DR Ensembl; ENSMZET00005010261.1; ENSMZEP00005009898.1; ENSMZEG00005007380.1.
DR GeneTree; ENSGT00940000155359; -.
DR Proteomes; UP000265160; LG16.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR CDD; cd01397; HAT_MBD; 1.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028942; WHIM1_dom.
DR PANTHER; PTHR45915:SF8; BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B-LIKE ISOFORM X1; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF15612; WHIM1; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 364..435
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 712..777
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT REGION 57..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 537..571
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 640..686
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 66..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..175
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..944
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..959
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 969 AA; 108804 MW; 9A3EBFC9309EDE23 CRC64;
MESGRPLASS PEPFFLHMAS SKANWWRTSE TQTRAAAAFF PPLLGLHPFV LSTFKSHDPV
DFQSRPSGKR SLSLGVNGTV NGRSASSPAG NAPAMNTSSL LAKGKKETPQ ANSHEPGQLH
QKAVEKKPNK RPLETSSMSG SQSESQSESS SEVEESSSDP DDMEEEDDDD QSSDSEESGY
EKQSPAKQKV KVSASLELLC KQRVYRISEL FSLHISSSNM FLNLYPNGAI NGAVQDAPLA
LITKPRIQSS TPNSKPLLAA TSPPCSMPIN LSTGTKEMLD SSASPLKTSA SSEPRSRKTT
QTVHSGRSLT RTNTSCLPVD LVRGSEPDIH SSKNSDDSLG DDYDEDEDED SGSSFSGSGR
RRRVTDERVL RLPLEFGWQR ETRIRTVAGR LQGEVAYFAP CGKKLRQYPD VVKYLIRNGI
TEISRDNFSF STKIKVGDFY EAREGPEGIQ WFLLAEDEIA PSIIAMDGRR SRRTKSEHQP
TGDSTGAIQW KPYPLNGGEN NFQDVSDAKL LRKLEAQEIA RQAAQIKMMR KLEKQAIAQA
AKEAKKQQAI MAAEERRKKR EQLKILKQQE KIKRIQQIRM EKELRAQQIL EVCPESYCRN
ILKHFLSAVD RIYRKKKKSN QRLFLNYVER ERRRQHMILM KAVEARKKAE EKERLKKEKK
DEKQLNKERK LELRRLELEK AKELKKPNED MCLADHKPLP ELSRIPGLVL AGSTFSNCLM
VLQFLHSFGK VLGLDLNSDP LTIGDLQEGL LNIAENMEKV QDLLVTMLSA AVCDPGVPAG
HKSKTILGDN LTNVEINRDN VSEILQIYME GHSEQKEVAM LAFSLRTKPF QAHSPSQKAS
VLAFLVNELC CSKVVISEID KNIDYMTNLR KDKWVVEGKL RKLRSIHTKK TGKKDNSWAG
ENNHAFVLVS VQNKSKRKEG DSEEEEDEDD DSEDQRDDEE EEEEEAGGKR GKKTDICEEE
VSGNIMLLT
//
