ID A0A3P9BJG5_9CICH Unreviewed; 891 AA.
AC A0A3P9BJG5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=SLCO5A1 {ECO:0000313|Ensembl:ENSMZEP00005010057.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005010057.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005010057.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
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DR AlphaFoldDB; A0A3P9BJG5; -.
DR STRING; 106582.ENSMZEP00005010057; -.
DR Ensembl; ENSMZET00005010423.1; ENSMZEP00005010057.1; ENSMZEG00005007613.1.
DR GeneTree; ENSGT01080000257410; -.
DR OrthoDB; 2874223at2759; -.
DR Proteomes; UP000265160; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR CDD; cd17404; MFS_SLCO5_OATP5; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF142; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 2.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 186..207
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 214..235
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 322..346
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 366..387
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 447..471
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 491..512
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 524..544
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 668..694
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 715..737
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 757..780
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 147..781
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 568..624
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 810..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 891 AA; 96964 MW; B7B01FEE10CD1EA7 CRC64;
MMADHEEAEL SESLQKEDGF SSEVEDPGTN FKSKSLPVLS EAAPQEKTLL ASSVRMSITA
EESTEFIQNP PNTESFQAES PTRANYPPKP GKSALNRPAS YMENTEIRRS KHMARRKPPG
FFAARLAQIR LPSRKHLGVI LQDSRCFLFC MCYLTFIQSL MVSGYLSSVI TTIEKRYSLR
SSESGLLVSC FDIGSLLVVV FISYFGGRGQ RPRWLAVGGI FIAVGAALFS LPHFISPPYQ
IQEVNSSSAN EGLCMNSNAS SRDRVDITSC PRDQEGNEHN LYVALFVIAQ ILVGMGSTPI
YTLGPTYLDD NVKKENASLY LAIMYVMGAL GPAAGYLLGG VLIGFYVDPK TVVNIDQSDP
RFIGNWWSGF LLCAIAMLLV IFPMFTFPKK LPPRHKKKKR RKKLSLDDLS SDDDVLKEKS
NNKTQTVTSS MGFGKDIKDL PKAAVRILSN VTFLFVSLSY TAESAIVTAF ITFIPKFIES
QFGIPASNAS IYTGVIIVPS AGVGIVLGGY IIKKLKLGAR ESAKLAMICS GVSLLCFSTL
FIVGCESINL GGINIPYTTG PTLTMTQRNL TGGCNVNCGC KIHEYAPVCG SDGITYFNPC
LAGCGSVAND STGIRNYSDC ACVQSRQVIT PSTGSQGSNQ LQLVIVKTYL NENGYAVSGK
CDRTCNTLIP FLIFLFIVTL ITACAQPSAI IVTLRSVAEQ ERPFALGMQF VLLRTLAYIP
TPIYFGAVID TTCMLWQQDC GVHGSCWEYD VTSLRFVYFG LAASLKFLGF FFIFLTWYSI
KYKEERVERW LKRHLSPVDT VGSLVCHPGG HKGHARTRSC PVNIPRTDPN ALPANAPPRA
GTLNRGVSTQ SCPGQELKAI TPPPAAAAAP SPAAAPSPAP AQSLEHVSVR V
//
