ID A0A3P9BJL4_9CICH Unreviewed; 943 AA.
AC A0A3P9BJL4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Sorting nexin 13 {ECO:0000313|Ensembl:ENSMZEP00005010144.1};
GN Name=SNX13 {ECO:0000313|Ensembl:ENSMZEP00005010144.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005010144.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005010144.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005010144.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR AlphaFoldDB; A0A3P9BJL4; -.
DR Ensembl; ENSMZET00005010512.1; ENSMZEP00005010144.1; ENSMZEG00005007619.1.
DR GeneTree; ENSGT00950000182856; -.
DR Proteomes; UP000265160; LG22.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06873; PX_SNX13; 1.
DR CDD; cd08719; RGS_SNX13; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037437; SNX13_PX.
DR InterPro; IPR037896; SNX13_RGS.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF3; SORTING NEXIN-13; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 31..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 98..283
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 372..512
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 548..670
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 943 AA; 109524 MW; DDA2A6B546761AC3 CRC64;
MLTRSSHLSI WGWGGLGVVL FLVTFGPFAI FYLAFYIFCF IGGGFAVTLL YGKINSEKHL
EKCEHSYLPP TQIGILKTLD EMKLEMKPIK IDRRLTGSSF IDEPLQQVIQ FALRDYIQYW
YYTLSEDESF LLEIRQTLQN ALVQFSTRSK EVDWQPYFTT RLVDDFATHL RVFRKAQDRL
GDREDKLSTY DLMESFFEAE VEMERKICRD VVCTSHKDEE GFLRDLCELL LYLLLPPGDF
HNKNMRYFLR EVLARGVLLP LINQLSDPDY INQFVIWMIR DNSCNYEAFM NILKLTDKPA
ELEAVRDKVL EELQFLRSLD TAGDDINVIK NQINSLLFVK KVCETRIQRL QSGKEVDAFK
LAANFGKLCV IPLDHILVHN IALQFFMDFM QAAGAQAELF FWLTVEGYRV TAQQQLEAMQ
SWQKDGKKQP SDTKGLLKAA ALGVYEQYLS DKASPRVQVD EASLTRLGEK LRKDDPTPEI
FDEIQRKVYD MMLRDERYYP SFKQSPLYVR MLAELDMLKE PSYRGSDDGD GESFNGSPTG
SINLVTDACL PGFWGAAGVC NDHGKTYALY TITVVRRNQD GSEDAWKTYR RYSDFHDFHM
RITEQFENLA SILKLPGKKT FNNMDRDFLE KRKKDLNAYL QLLLNPEMVK ACPTLIPYVY
DFLENKAYSK GKGEFARKID TFVNPLRSSM RNVSNAVKAF PDSLAEGVTK VSDNMGRMSE
KLGQDIKQSI LKVPPILPKS EIDPEHCRVS AQLDDNVDDN IPLRVMLLLM DEVFDLKEKN
QWLRRNIKNL LQQLIRATYG DTINRKIVDH VDYLTSPEQV ADYVKRFRDS YWPNGILAET
PPRRDKNIRM RTRVAAKTSL LGIMPDELKH IIGADTTRKG ILRVFDMFQY QPMNRRLVYV
FLEGFLETMF PQYKFPELFV KLHSRSPRIH RYNQKLKSTS LKR
//
