ID A0A3P9BJM6_9CICH Unreviewed; 954 AA.
AC A0A3P9BJM6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Sorting nexin 13 {ECO:0000313|Ensembl:ENSMZEP00005010117.1};
GN Name=SNX13 {ECO:0000313|Ensembl:ENSMZEP00005010117.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005010117.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005010117.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005010117.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR AlphaFoldDB; A0A3P9BJM6; -.
DR STRING; 106582.ENSMZEP00005010117; -.
DR Ensembl; ENSMZET00005010485.1; ENSMZEP00005010117.1; ENSMZEG00005007619.1.
DR GeneTree; ENSGT00950000182856; -.
DR Proteomes; UP000265160; LG22.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; IEA:Ensembl.
DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR CDD; cd06873; PX_SNX13; 1.
DR CDD; cd08719; RGS_SNX13; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037437; SNX13_PX.
DR InterPro; IPR037896; SNX13_RGS.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF3; SORTING NEXIN-13; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 30..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 97..284
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 373..513
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 559..681
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 954 AA; 110874 MW; 5E38305C0D1FD75A CRC64;
MFAEASLSIW GWGGLGVVLF LVTFGPFAIF YLAFYIFCFI GGGFAVTLLY GKINSEKHLE
KCEHSYLPPT QIGILKTLDE MKLEMKPIKI DRRLTGSSFI DEPLQQVIQF ALRDYIQYWY
YTLSEDESFL LEIRQTLQNA LVQFSTRSKE VDWQPYFTTR LVDDFATHLR VFRKAQDRLG
DREDKLRDIT DDLMESFFEA EVEMERKICR DVVCTSHKDE EGFLRDLCEL LLYLLLPPGD
FHNKNMRYFL REVLARGVLL PLINQLSDPD YINQFVIWMI RDNSCNYEAF MNILKLTDKP
AELEAVRDKV LEELQFLRSL DTAGDDINVI KNQINSLLFV KKVCETRIQR LQSGKEVDAF
KLAANFGKLC VIPLDHILVH NIALQFFMDF MQAAGAQAEL FFWLTVEGYR VTAQQQLEAM
QSWQKDGKKQ PSDTKGLLKA AALGVYEQYL SDKASPRVQV DEASLTRLGE KLRKDDPTPE
IFDEIQRKVY DMMLRDERYY PSFKQSPLYV RMLAELDMLK EPSYRGSDDG DGESFNGSPT
GSINLSLDDL PNSCHDESMH LHAFISDTGV CNDHGKTYAL YTITVVRRNQ DGSEDAWKTY
RRYSDFHDFH MRITEQFENL ASILKLPGKK TFNNMDRDFL EKRKKDLNAY LQLLLNPEMV
KACPTLIPYV YDFLENKAYS KGKGEFARKI DTFVNPLRSS MRNVSNAVKA FPDSLAEGVT
KVSDNMGRMS EKLGQDIKQS ILKVPPILPK SEIDPEHCRV SAQLDDNVDD NIPLRVMLLL
MDEVFDLKEK NQWLRRNIKN LLQQLIRATY GDTINRKIVD HVDYLTSPEQ VADYVKRFRD
SYWPNGILAE TPPRRDKNIR MRTRVAAKTS LLGIMPDELK HIIGADTTRK GILRVFDMFQ
YQPMNRRLVY VFLEGFLETM FPQYKFPELF VKLHSRSPRI HRYNQKLKST SLKR
//
