ID A0A3P9BJV9_9CICH Unreviewed; 963 AA.
AC A0A3P9BJV9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Probable ribonuclease ZC3H12C {ECO:0000313|Ensembl:ENSMZEP00005010215.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005010215.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005010215.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005010215.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the ZC3H12 family.
CC {ECO:0000256|ARBA:ARBA00010922}.
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DR RefSeq; XP_004573649.1; XM_004573592.1.
DR RefSeq; XP_004573650.1; XM_004573593.1.
DR RefSeq; XP_004573651.1; XM_004573594.1.
DR AlphaFoldDB; A0A3P9BJV9; -.
DR STRING; 106582.ENSMZEP00005010215; -.
DR Ensembl; ENSMZET00005010584.1; ENSMZEP00005010215.1; ENSMZEG00005007718.1.
DR GeneID; 101478303; -.
DR KEGG; mze:101478303; -.
DR GeneTree; ENSGT00940000155107; -.
DR OrthoDB; 180910at2759; -.
DR Proteomes; UP000265160; LG23.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd18729; PIN_Zc3h12-like; 1.
DR Gene3D; 3.40.50.11980; -; 1.
DR InterPro; IPR040546; Rege-1_UBA-like.
DR InterPro; IPR040757; Regnase_1/ZC3H12_C.
DR InterPro; IPR021869; RNase_Zc3h12_NYN.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR12876; N4BP1-RELATED; 1.
DR PANTHER; PTHR12876:SF36; RIBONUCLEASE ZC3H12C-RELATED; 1.
DR Pfam; PF18561; Regnase_1_C; 1.
DR Pfam; PF11977; RNase_Zc3h12a; 1.
DR Pfam; PF18039; UBA_6; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 420..445
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT ZN_FING 420..445
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 29..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..736
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..754
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..846
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..889
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 963 AA; 104360 MW; B68081AA642E8039 CRC64;
MGQKDHVEAG SGHILDLGLD LEYLHVAGGD RQAGGADGPP AMEEQGESTA GSPPLTVLEE
NSGFDAEGES ALTSSSTLAP GTDSDGGDGG STHSKNTHQP LCRTQCVDLG TEGPPEPPSE
LLAELECDAH AQSTLGSPSE HLPEPPPSLS ASEPGYEAGG KEYQAKLEFA LKLGYSEETV
RLVLSKLGPD TLINDILGEL VKLGTKSDSE QPAGLLASTS SSSSSSSSCG CSDLLEGQRP
DSPCHSDSLC DQDNLRPVVI DGSNVAMSHG NKEVFSCQGI QLAVDWFLER GHQDITVFVP
AWRKEQSRPD APITDQDILR RLEKEKILVF TPSRRVQGRR VVCYDDRFIV KLAYESDGII
VSNDNYRDLA NEKPEWKKFI DERLLMYSFV NDKFMPPDDP LGRHGPSLDN FLRKRPVMPE
QKKQPCPYGK KCTYGHKCKY YHPERGAQPQ RAVADELRAS AKTCVVSKNQ GDAGLVKSHS
VPAGSIDAKK GAPKRQSDPS IRALSYSDAE EKLLAKGRLE VQKNTVCGSS SSSSTSGSCG
GSVSMSPAPG GPPSTLGLPQ EQQARPVMPH GHLPAPSHDL YPHCESPDLS YYSVTRAYTG
LSLSSRRSPD CRFPNDTDLR LGSAGSECSS ESSVSCGSSC DLYSERQCPG CPPDPLLEDA
VHFPNPHSRL YSHHATSSHE LCGLHPAEYT NIQHSHTPST GLHPYHLSAA HGQSCAHDPP
PLEAPPKRPL YPLPPHLQHQ PLTARSSCPG DYHSLPQSNP APPGSPLGRC LAPTRAESVS
DSHLYEHLST SHHRHRPKAL PSWDKYYRQP PLPPSRYEPP TYQSLPDTRQ SSWHTPPWTQ
DGYGQHHSSH PALHPSPTHY LSHPPPPAHS PCPPHPSSTP LPPYPPHSSH LTVPSHAPPS
YMSQHPESPS HSRYGDAREK VYINLCNIFP SELVSRVMAR SPHITDPQQL AAAILAEKAQ
TGY
//
