ID A0A3P9BKV7_9CICH Unreviewed; 2087 AA.
AC A0A3P9BKV7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Dedicator of cytokinesis protein 11 {ECO:0000313|Ensembl:ENSMZEP00005010562.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005010562.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005010562.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005010562.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_004567160.1; XM_004567103.1.
DR STRING; 106582.ENSMZEP00005010562; -.
DR Ensembl; ENSMZET00005010934.1; ENSMZEP00005010562.1; ENSMZEG00005007842.1.
DR GeneID; 101469146; -.
DR KEGG; mze:101469146; -.
DR CTD; 139818; -.
DR GeneTree; ENSGT00940000155658; -.
DR OrthoDB; 5480873at2759; -.
DR Proteomes; UP000265160; LG3.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF81; DEDICATOR OF CYTOKINESIS PROTEIN 11; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 165..272
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 662..834
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1633..2060
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 431..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1264..1290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2087 AA; 237076 MW; 0AB2F46CB6318631 CRC64;
MSEVRKFTKR LSKPGTAAEV RQSVSEAVRT TVDLVEQPKI IEPLDYEAVV FQRKAQIHSD
PHRDLLLCPV DDVSESQISR QRRTVVPSVP QNAEREARSL FAKECIKMYN TDWHVINYKY
EAYSGDFRML PSKGLKTDKL PAHVFEIDED AKDEDSASLC SQRGGILKQG WLQKANINSS
LSVSMRVFKR RYFYLSQLPD GSYILNSYKD EKNCKETKGS IYLDSCIDVI QSPKMRRNGF
ELKMQDRYSH FLAADSEAEM EEWVATLKQA LQSSTEAGQD RRNGAESLDC VLDDDTASQG
KGESMLENSG RSLHTELIKY TRETDQLSKM NRNEGRLKLS SLDPETQRLD FSGIEPDVKP
FEERFGRRIV VSCHDLTFSL QGCVNEKGDG VLTNVEPFFI SLALFDVSKS CKISADFHVE
LNPPSVREML TDTSTQASPS SDSDGGGGVK DGGQGGVLVN GDSGKGNGLP LLQRVSEALL
RFPTQGIFSV TNPHADIFLV ARVEKVLQNG ITHCAEPYMK TSDITKTAQK VLKAAKQTCQ
RLGQYRMPFA WAAKQVFKDA QGSLDMDGKF SPLYRQDSSK ISTDDLIKLL ADIRKPEKSK
LQIIPGQLNV TIECVPPDFS NTVTSSYIPV KPFEDGCERV SVEIEEFLPE EAKYNYPFTT
YKNQLYVYPL QLKYDNQKTF TKARNIAICI QFRDSDEEGA APLKCIYGKP GDSLFTSSTY
AAVLHHNQSP DFYDEVKIEL PVHVHEKHHI LFTFYHISCE SSSKASSKKR DGVESLVGYS
WMPLLKDGRM QSLEFQLPVA ATLPAGYLCQ DTRKADIKWV ENAKTLFKVR THVASTIYPQ
DLHLHKFFQH CQLMRTASEG NPAELIKYLK CLHAMETHVI ITFLPTVLMQ LFEVLTAATK
EAHEIAVNSL RVIIHIVSKC HEEGLEHYLR SFVKYVFVTN NPASGNSVTT HELLATAVTA
TLKQTADFNT SNKLLKYSWF FFETMAKSMA QYLQEENRMK MPRAQRFPES FHQALQSLVL
SIMPHITIRH SEIPEEARCI NLSLANFIKR CLTVMNRGFG FGLVNHYMCH FSPKDPKVLT
EMKFDFLMTL CNHEHFIPLN LPMAFGRTKL QRVQDFIPYA TELFGPVEQS LEFSLTEEYC
RNHFLVGLLL REVADALQQA PEVRQQAVGI LKNLLIKHAM DDRYTAFKNQ QARICLLYLP
LYELLYQNLK QLSAQPLISS PGLGLNGSRD DLISTDMRRI STAIEKEHGQ PTQNGHVVRR
EDSRGSLFMD PGTPDSNELQ RRASTMSSST MPPIGRLGQY EIKGLLFSFL HIAKTLSEDT
LMAYWNKISP QDIMNFLSLL EVCLAQFRYI GKRNIGRSQE ACVSKLFSSG GKSQTMPPMR
CNRASLMQSK IHQFNTMEAS FTLNIWAGLS EAEIHHQALL EGNTSTEVCL SVLDILSLFT
QCFKNQLLDS DGHNALMKKV FDVYLTFLKV GQSEAALRHV FAALRAFINK FPSVLFKGRV
TLCEALCCEV LKCCVSKLAS LRAEASALLY LLMRNNYEYT KRKTFLRTHL QIIIAVSQLI
SDVALTGSSR FQESLSIINN FANSDKAMKS TAFPSEVKGL TKRIRTVLMA TAQMREHEKD
PEMLLDLQYS LARSYASTPE LRRTWLDSMA RAHLKNGDLS EAAMCYVHVA ALVAEYLNRK
KLFPSGLAAF KKITFNIDEE AAMKEDAGMQ DVYYTEEVLV EHLEVCVDAL WKAERYEVIT
HIAKLVIPIY EKRHEYEKLS RLYETLHRAY NKIMEVIQSG RRLLGTYFRV AFYGQGFFEE
EDGKEYIYKE PKLTGLSEIS QRLLTLYGEK FGPENVKIIQ DSNKVNPKDL DPKFAYIQVT
FVKPHFEEKE APEKKTDFEK CHNISRFVFE TPYTLSGKKH GGVEEQCKRR TILITANTFP
YVKKRVEVVA EKQVELKPVD VAIDEMKART AELIKLCSSQ EVDMIQLQLK LQGCVSVQVN
AGPMAYARAF LDDSKSNQSG NKKVKELKDV FRRFVEACSM ALDINERLIK EDQFEYHEGL
KTNFKEMVKE LSDIIHEQIY PEDMMRSLLQ NSLHVFRAIS GTSTDLG
//
