ID   A0A3P9BKX5_9CICH        Unreviewed;      1241 AA.
AC   A0A3P9BKX5;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Cullin-associated NEDD8-dissociated protein 1 {ECO:0000313|Ensembl:ENSMZEP00005010311.1};
OS   Maylandia zebra (zebra mbuna).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX   NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005010311.1, ECO:0000313|Proteomes:UP000265160};
RN   [1] {ECO:0000313|Ensembl:ENSMZEP00005010311.1, ECO:0000313|Proteomes:UP000265160}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA   Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA   Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA   Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA   Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA   Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA   Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA   Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA   Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA   Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA   Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA   Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid fish.";
RL   Nature 513:375-381(2014).
RN   [2] {ECO:0000313|Ensembl:ENSMZEP00005010311.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CAND family.
CC       {ECO:0000256|ARBA:ARBA00007657}.
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DR   RefSeq; XP_004559094.1; XM_004559037.1.
DR   AlphaFoldDB; A0A3P9BKX5; -.
DR   STRING; 106582.ENSMZEP00005010311; -.
DR   Ensembl; ENSMZET00005010682.1; ENSMZEP00005010311.1; ENSMZEG00005007781.1.
DR   GeneID; 101484714; -.
DR   KEGG; mze:101484714; -.
DR   CTD; 23066; -.
DR   GeneTree; ENSGT00390000017740; -.
DR   OrthoDB; 68829at2759; -.
DR   Proteomes; UP000265160; LG5.
DR   GO; GO:0010265; P:SCF complex assembly; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039852; CAND1/CAND2.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR013932; TATA-bd_TIP120.
DR   PANTHER; PTHR12696:SF2; CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 2; 1.
DR   PANTHER; PTHR12696; TIP120; 1.
DR   Pfam; PF08623; TIP120; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REPEAT          49..87
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   DOMAIN          1049..1212
FT                   /note="TATA-binding protein interacting (TIP20)"
FT                   /evidence="ECO:0000259|Pfam:PF08623"
SQ   SEQUENCE   1241 AA;  136671 MW;  B9B3F4F0738A3E58 CRC64;
     MSSVSYHISN LLEKMTSTDK DFRFMATNDL MLELQKDSIK LDEDSERRVV TMLLKLLEDK
     NGEVQNLAVK CLAPLVSKVK EPQVETMVDV LCSNMTSDKE QLRDISSMGL KTVIAELPLT
     SSGLTLTGSV CKKITSQLIG AMGKHDDVSV QLEALDILSD MLGRLSGALV SFHSSLLSSL
     LPQLTSPRMA VRKRSILALG HLVPCCSPAL FSQLTEHLMK ELAKGPPTSM TRTYIQCLAT
     ISRQGGHRVG EHLEKLIPMV VKFTGVEDDE LREYCFQAFE AFIRRCPKEM SPHIATVTQL
     CLKYMTFDPN YNYDDNEEED EDRMDIDDEL EEESDDEYSD DDDMSWKVRR SSIKCLEALI
     STRLDLLLSF YSSICPALLA RFKEREENVR ADVFTAFSTL LRQTRVASSR HSLIVSGSDP
     GVRREEEAAV ALLKKQVPAT VKALHRQLKE KSIKSRQGCF CLLTELAHTV PGALEEHIPA
     LIPGIVFSLT DKSTLSTMRI DALSFFNVLL LSHPPQAFQP HMQVLLPPVI ACIEDTFYKI
     TSEALLVIQH LVKVMRPQGQ AGGFDPKPFV KEVFSATMKR LKATDIDQEV KERAISCMGH
     IVCHLGDHLR AEVQAVLAIF LERLKNEITR LTAVRTITLI AASPLKIDMS PILPEALSVL
     GSFLRKNQRA LKLGTLACLT ALVTHHAASI KPAALEPVLS ELPTLVDESD MHVSQVSITL
     LTGMAKAYPS TLAKISSSVL PGVFRLIHSP LLQGSTLEAI LEYLQALVLS KTSNLSYSQL
     LKSLMEPFHR SQSSADGSIV HRQSYHSVAH CVAALSSASP KETPGTVAGF IQQVKNPGSP
     EAARVLALLC LGEVGRKGSL GGSKEVQGVI LEAFSSTSEE VKTAASCALG SMAVGCLSDY
     LPFLLKEISA QPRRQYLLLH SLKEVISVCP ASSLSPHVES VWALLFQNCE CQEEGTRNLV
     AECLGKLTLV NPAALLPRLK QQLKTGSPLA RSTVVTAIKF TIVDHPAPID SLLKDCIGDF
     LKTLQDEDIN VRRIALVMFN SAAHNKPSLI RGLLGRVLPH LYKETQIRKD LIREVEMGPF
     KHTVDDGLDV RKAAFECMYS LLDSCLEGLD ILQFLDHVEE GLKDHYDIRM LTFLMLARLV
     SLCPAAVLQR LDRLVEPLKA TVTTKVKAGS VKQEFEKQEE LRRSAMRAVA ALLAVPEVER
     SPSMAEFANQ IKTSTDMASI YQSIKGGEGG GIGATESMDM S
//