ID A0A3P9BL97_9CICH Unreviewed; 297 AA.
AC A0A3P9BL97;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Neuralized E3 ubiquitin protein ligase 2 {ECO:0000313|Ensembl:ENSMZEP00005010697.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005010697.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005010697.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005010697.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_012777628.1; XM_012922174.1.
DR STRING; 106582.ENSMZEP00005010697; -.
DR Ensembl; ENSMZET00005011072.1; ENSMZEP00005010697.1; ENSMZEG00005008051.1.
DR Ensembl; ENSMZET00005011077.1; ENSMZEP00005010702.1; ENSMZEG00005008051.1.
DR GeneID; 101474789; -.
DR CTD; 140825; -.
DR GeneTree; ENSGT00940000159689; -.
DR OrthoDB; 3661067at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000265160; LG8.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd12887; SPRY_NHR_like; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR037962; Neuralized.
DR InterPro; IPR006573; NHR_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR12429; NEURALIZED; 1.
DR PANTHER; PTHR12429:SF8; NEURALIZED-LIKE PROTEIN 2; 1.
DR Pfam; PF07177; Neuralized; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00588; NEUZ; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS51065; NHR; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 8..171
FT /note="NHR"
FT /evidence="ECO:0000259|PROSITE:PS51065"
FT DOMAIN 262..297
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 119..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 297 AA; 33517 MW; FAAB92AACA12F48B CRC64;
MEPVSDQFMQ FHPIHGTNVR LDHSGTQATR VESFANGVCF SKCPLKPGEI FLIEIEDKEL
GWCGHLRIGL TARDPRSLEV VPEYSIPNLT DLGDSWIFAI TRNHNKIVEE AEVLEPRQGE
LVGGRRLGRG EEEDGAGDQA DERTARNRKP KTFFTDTHLY IENVRIPRDK LVGRSRPGRY
SHILDDLYKT NALPPTARRS RIGVLYVPRG EGLADMHIVI NGEDMGASAK RISTAGPLYA
VVDVFAATKC VRIVQVEYGF SSLQTLCRKA IQKHIVHRMA IDWLELPEAL KHYCKYE
//
