ID A0A3P9BM01_9CICH Unreviewed; 848 AA.
AC A0A3P9BM01;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Patched domain-containing protein 3-like {ECO:0000313|Ensembl:ENSMZEP00005010955.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005010955.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005010955.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005010955.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR AlphaFoldDB; A0A3P9BM01; -.
DR Ensembl; ENSMZET00005011334.1; ENSMZEP00005010955.1; ENSMZEG00005008217.1.
DR GeneTree; ENSGT00940000158727; -.
DR Proteomes; UP000265160; LG18.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR10796:SF60; PATCHED DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 677..695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 702..724
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 730..753
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 765..791
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 803..826
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 259..416
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT DOMAIN 668..825
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 848 AA; 95332 MW; DA40F087AFBEBCD8 CRC64;
MARCRMDCIE KPLQSFFKKM GKSVGSNPWW FLIAPLIVSA ALGSGFYFTQ DRISNNIEEE
FTPFNGPAKT ERKYFSEMFP EDDSMFSSLR QTTDGNYATL IATSETNILT VKMLEEILML
DSKIKNMLVE FDKESFKYEG ICAKVMKNCI SNIILDIIQY NAENIKAVTL TFPWYHNGNT
NLPLYTSLGG VTQGDTSVVE SAKAIQLYYY LKEGNKTKND LWLESFISLV SNSSSPSLQV
SYSTSMSMQW EFEKSPDSVI SLFSITYSIA ITFSIITCWR LDNVRTKVWV GFCGVLSTSL
AVVSGFGLLL LVGQPFVMTA ASCPFMILGI GIDDMFIMIS CWQQTRVLDS VPKRLGETYK
DAAISITITT LTDVLALFLG CITPFGSVQS FCLYAGICLC FCYFYSLTFL GACMALNGQR
EAENKHWITC IEVPSDAPGK SKAFWLCCTG GRYNKDTAKE ETEPISSFFE KFYGPFLTHK
VTKVFVFVLY AGYLAASIYG CVILKEGLDT KNLALDDSYI INYYNHEEEH FNEYSFSAMV
AIEQQFPYWD KDQRKQLNSC ISSFESLKFV NNTMAWFIFF ENYAEANNKS ISSQEDFLNN
LKPFLNFDPF LAQDIQWTPD DKIQVSRFFL QTKNNVPMAD MMVELRKTAE ECSVELLVYH
PSFIYFDQYT VILNNTIQTM LTAVIVMLAI SLVLIPDPLC SLCVVFAIVS VITGVTGFMS
LWGVNLDSIS MINLVMCIGF SVDFSAHICY SFVSSPKSDA NEKAIEALAI LGYPVLQGAL
STILGVVVLS VSGSYIFRTF FKIVFLVIVF GLFHGLTFIP VFLTLFGRFL MRLAPTPTNI
SSNSEPEA
//