ID A0A3P9BM23_9CICH Unreviewed; 1884 AA.
AC A0A3P9BM23;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Dedicator of cytokinesis protein 11 {ECO:0000313|Ensembl:ENSMZEP00005010696.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005010696.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005010696.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005010696.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR Ensembl; ENSMZET00005011071.1; ENSMZEP00005010696.1; ENSMZEG00005007842.1.
DR GeneTree; ENSGT00940000155658; -.
DR Proteomes; UP000265160; LG3.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF81; DEDICATOR OF CYTOKINESIS PROTEIN 11; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 164..271
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 622..817
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1433..1860
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
SQ SEQUENCE 1884 AA; 215100 MW; 36A1D158E264A1A9 CRC64;
MSEVRKFTKR LSKPGTAAEV RQSVSEAVRT TVDLEQPKII EPLDYEAVVF QRKAQIHSDP
HRDLLLCPVD DVSESQISRQ RRTVVPSVPQ NAEREARSLF AKECIKMYNT DWHVINYKYE
AYSGDFRMLP SKGLKTDKLP AHVFEIDEDA KDEDSASLCS QRGGILKQGW LQKANINSSL
SVSMRVFKRR YFYLSQLPDG SYILNSYKDE KNCKETKGSI YLDSCIDVIQ SPKMRRNGFE
LKMQDRYSHF LAADSEAEME EWVATLKQAL QSSTEAGQDR RNGAESLDCL AYIAAVCLQY
TRETDQLSKM NRNEGRLKLS SLDPETQRLD FSGIEPDVKP FEERFGRRIV VSCHDLTFSL
QGCVNEKGDG VLTNVEPFFI SLALFDVSKS CKISADFHVE LNPPSVREML TDTSTQSVLR
KDPRKLPNQI PTTCLDCFIS PSLLQGIFSV TNPHADIFLV ARVEKVLQNG ITHCAEPYMK
TSDITKTAQK VLKAAKQTCQ RLGQYRMPFA WAAKQVFKDA QGSLDMDGKF SPLYRQDSSK
ISTDDLIKLL ADIRKPEKSK LQIIPGQLNV TIECVPPDFS NTVTSSYIPV KPFEDGCERV
SVEIEEFLPE EAKYNYPFTT YKNQLYVYPL QLKYDNQKTF TKARNIAICI QFRDSDEEGA
APLKCIYGKP GDSLFTSSTY AAVLHHNQSP DFYDEVKIEL PVHVHEKHHI LFTFYHISCE
SSSKASSKKR DGVESLVGYS WMPLLKDGRM QSLEFQLPVA ATLPAGYLSN VDPSLRTHVA
STIYPQDLHL HKFFQHCQLM RTASEGNPAE LIKYLKCLHA METHVIITFL PTVLMQLFEV
LTAATKEAHE IAVNSLRVII HIVSKCHEEG LEHYLRSFVK VSCRKHCLLT THELLATAVT
ATLKQTADFN TSNKLLKYSW FFFETMAKSM AQYLQEENRM KMPRAQRFPE SFHQALQSLV
LSIMPHITIR HSEIPEEARC INLSLANFIK RCLTVMNRGF GFGLVNHYMC HFSPKDPKVL
TEMKFDFLMT LCNHEHFIPL NLPMAFGRTK LQRVQGKSSL EFSLTEEYCR NHFLVGLLLR
EVADALQQAP EVRQQAVGIL KNLLIKHAMD DRYTAFKPNL QSLDPNKPIL VAGQPTQNGH
VVRREDSRGS LFMDPGTPDS NELQEQGLML FLFLLPSCSC YYRYRSQEAC VSKLFSSGGK
SQTMPPMRCN RASLMQRLQL ESVLHHNVNH YVLDILSLFT QCFKNQLLDS DGHNALMKKV
FDVYLTFLKV GQSEAALRHV FAALRAFINK FPSVLFKGRV TLCEALCCEV LKCCVSKLAS
LRAEASALLY LLMRNNYEYT KRKTFLRTHL QIIIAVSQLI SDVALTGSSR FQESLSIINN
FANSDKAMKS TAFPSEVKGL TKRIRTVLMA TAQMREHEKD PEMLLDLQYS LARSYASTPE
LRRTWLDSMA RAHLKNGDLS EAAMCYVHVA ALVAEYLNRK KLFPSGLAAF KKITFNIDEE
AAMKEDAGMQ DVYYTEEVLV EHLEVCVDAL WKAERYEVIT HIAKLVIPIY EKRHEYEKLS
RLYETLHRAY NKIMEVIQSG RRLLGTYFRV AFYGQGFFEE EDGKEYIYKE PKLTGLSEIS
QRLLTLYGEK FGPENVKIIQ DSNKVNPKDL DPKFAYIQVT FVKPHFEEKE APEKKTDFEK
CHNISRFVFE TPYTLSGKKH GGVEEQCKRR TILITANTFP YVKKRVEVVA EKQVELKPVD
VAIDEMKART AELIKLCSSQ EVDMIQLQLK LQGCVSVQVN AGPMAYARAF LDDSKSNQSG
NKKVKELKDV FRRFVEACSM ALDINERLIK EDQFEYHEGL KTNFKEMVKE LSDIIHEQVI
LFPRAQLIRH LSVLGVGKSH SALI
//
