ID A0A3P9BMB7_9CICH Unreviewed; 1020 AA.
AC A0A3P9BMB7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Uncharacterized LOC101467170 {ECO:0000313|Ensembl:ENSMZEP00005011075.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005011075.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005011075.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005011075.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_004570952.1; XM_004570895.3.
DR AlphaFoldDB; A0A3P9BMB7; -.
DR STRING; 106582.ENSMZEP00005011075; -.
DR Ensembl; ENSMZET00005011458.1; ENSMZEP00005011075.1; ENSMZEG00005008315.1.
DR GeneID; 101467170; -.
DR KEGG; mze:101467170; -.
DR GeneTree; ENSGT00940000163632; -.
DR OrthoDB; 5347495at2759; -.
DR Proteomes; UP000265160; LG17.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR001507; ZP_dom.
DR PANTHER; PTHR14002:SF52; -; 1.
DR PANTHER; PTHR14002; ENDOGLIN/TGF-BETA RECEPTOR TYPE III; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00100; Zona_pellucida; 1.
DR SMART; SM00181; EGF; 1.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00241; ZP; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS51034; ZP_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1020
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018192703"
FT TRANSMEM 983..1004
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 239..338
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 634..672
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 691..945
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
SQ SEQUENCE 1020 AA; 114276 MW; BD0A2DCE764F6881 CRC64;
MNSLQYSFVF FILVPHVISL GRCNDISFSL CWMSKGNDLD RKNGDIWLNG TSLKSIRKVG
KVTSVTLSPG VENQLTLQYG GSVQAWTLTV PQSPRIKFTK VRGRKQPLQH PTNATKDFLK
LLSPTEVFAC ENGTVYFQQE ENFFLALGHT MRLACKLVSR SPSMLLVSWE RNQPDVIYSH
NVTLYHVELG SYNTHTLDVT THNHYRFSAL DPCTLYMACV EIADTLSLAC LSTITDPDVP
ENFEVTSWNS SSISLSWDCP VNSKYSVFLL TAFHLNGTNH ITDEVSFWHK DNFEVSLSDL
QPCSRVKFGL QTVCQAGIES RYSKMVLNDG NSFHSNIEDL RQTLFGPTNY TLSWEVRNTS
SISMFRVFHE GVLQGTTLMN SYTVRGLLPC QQYQARVEAL CGDGVLMSPK TVTAQTGPYG
VSELTYHSND SAAVWTPSSP QQQAVGFVYE LSLKNGTTID SSRVSVTKLR LLGLEEGKTY
VLNVWEECDN QLESEHSHLF FMAANSSKEL HVKAGGPAHD MELELDYDNT GLTVVVPWKL
PEDLDNGTSE AKDKIEEIFN NKLQELLKDK PVRIKLDSFE PADEPDKTEI FFRAFDASQT
KENVPVPIED LLYYTGSLNA TNITVKGGVI YWDGPDLCAS KQPLCSHNSL CINTLGSYSC
VCQHGYYDVS SVTERAPASH PVCQEKGLFS RCLDKLMAGA IAKPYLHSRM GGAVAVKLND
GRCIVNESET LYYFRTSRKV SECGTEKQVN KTHINFQNTL SVTLTKGQMI SRRDLKVVWK
CVYPRHYVRN AQVSVDMEWL TSMTLVEFNS SVHLGLKMTL YRDESYTNSY RDAITLELED
TLFFQVALET NGSFAVDLLL QVKSCWTTES IDPHDPTQGV LLQDGCPVDP TFHWLSVNGL
AHRSRFSIQM FNMPKKLPLY FHCLASICGH DEDCRLKCTG KQHTKRSVSQ MESEGKHAAV
VSAGPLIVNT RVKSATPSYW AEYMTVIAIV AGSIGFLGVT VLLVSATKAI MTYYEQLRSQ
//
