ID A0A3P9BN54_9CICH Unreviewed; 635 AA.
AC A0A3P9BN54;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Prospero homeobox protein 1-like {ECO:0000313|Ensembl:ENSMZEP00005011367.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005011367.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005011367.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005011367.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3P9BN54; -.
DR Ensembl; ENSMZET00005011761.1; ENSMZEP00005011367.1; ENSMZEG00005008537.1.
DR GeneTree; ENSGT00940000154790; -.
DR Proteomes; UP000265160; LG19.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.10.500; Homeo-prospero domain; 1.
DR InterPro; IPR023082; Homeo_prospero_dom.
DR InterPro; IPR037131; Homeo_prospero_dom_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR039350; Prospero_homeodomain.
DR PANTHER; PTHR12198; HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26; 1.
DR PANTHER; PTHR12198:SF9; PROX2 PROTEIN; 1.
DR Pfam; PF05044; HPD; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51818; HOMEO_PROSPERO; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 481..635
FT /note="Prospero"
FT /evidence="ECO:0000259|PROSITE:PS51818"
FT REGION 80..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 200..262
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 80..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 635 AA; 71765 MW; 85CC6437BDC57C73 CRC64;
MNLSLPDQSM HSSSEGCIED DKADVMLPCF HRNMYDEPLA SYSNGSIISQ LLRKTIHSKR
ALDESPFYLS SSAVADCSQE DQSSVSSKDS TVEAASPSGH APTGASPEGE HAMSDHLQAK
RARVENIIRV MVGSPNSRQH GDSERSENEA RDTREAREAY RENKRKQRLP QHQEHNASAQ
VSRKPGSSSS DNCNTKDEEC HKLKEQLHSM QRLLRHLQEK FLQVYHQEEA EYDRDETEVG
CKDRIKNLQE TLKQELTRAV NDCVDRVFKN VSSKGLDLSP KQRICSSPEM QISTGAERKS
QQASSALDHS QAEGVGIKSR SLEYYESSEA HSPQDQTEAL SLVVRKPAVP PMSSITPTVK
RPYPVHQAPF QFSYSTPLHD SHILEHLLKY GPHSNFGGLP CLPPSMDRTS PDSVDLPWET
IAMRSKVTSS HLGHHARPSS LGGVTVDNLC LPHVKIECGE LQGMADRNPY MSLNISFHSL
TEGLTPSHLK KAKLMFFYTR YPSSNVLKTF FPDVKFNRCI TSQLIKWFSN FREFYYIQME
KFARQAIVDG VTDIKDMSVS RDSELFRALN MHYNKANDFH VPDRFLEVAE ITLHEFYNAI
SATKDSDPSW KKAIYKVICK LDSDVPEEFK TSSYL
//
