ID A0A3P9BNI0_9CICH Unreviewed; 760 AA.
AC A0A3P9BNI0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=U3 small nucleolar RNA-associated protein 25 homolog {ECO:0000256|ARBA:ARBA00024421};
DE AltName: Full=UTP25 small subunit processor component {ECO:0000256|ARBA:ARBA00032325};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005011490.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005011490.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005011490.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the UTP25 family.
CC {ECO:0000256|ARBA:ARBA00009223}.
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DR AlphaFoldDB; A0A3P9BNI0; -.
DR STRING; 106582.ENSMZEP00005011490; -.
DR Ensembl; ENSMZET00005011890.1; ENSMZEP00005011490.1; ENSMZEG00005008636.1.
DR GeneTree; ENSGT00390000000709; -.
DR OrthoDB; 5473087at2759; -.
DR Proteomes; UP000265160; LG19.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR GO; GO:0048546; P:digestive tract morphogenesis; IEA:Ensembl.
DR GO; GO:0048568; P:embryonic organ development; IEA:Ensembl.
DR GO; GO:0031017; P:exocrine pancreas development; IEA:Ensembl.
DR GO; GO:0090594; P:inflammatory response to wounding; IEA:Ensembl.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:Ensembl.
DR GO; GO:0035265; P:organ growth; IEA:Ensembl.
DR GO; GO:0030163; P:protein catabolic process; IEA:Ensembl.
DR GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
DR GO; GO:1902570; P:protein localization to nucleolus; IEA:Ensembl.
DR GO; GO:0048485; P:sympathetic nervous system development; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010678; UTP25.
DR PANTHER; PTHR12933; ORF PROTEIN-RELATED; 1.
DR PANTHER; PTHR12933:SF0; U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG; 1.
DR Pfam; PF06862; UTP25; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT REGION 1..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..70
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..145
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 760 AA; 87292 MW; 02BF4607ABADCCC6 CRC64;
MGKRKQNKQF LTTLSKKQKK HLKEFGEEHP FHDVVNERPE KTQVMELPSS PEQSESEADE
LEPEEEEEEP EQKTAYQKLL STLSQPRGEA QSEEEDSTDD EEEEEEEEEL LGEDEIDAEE
GSEGGDEDEK GEGEPADGEE ALMEAGDGED DRKELGDEFV DKEHESQFCL ETNFTGKGEQ
EETRDEDSKD MFVQHLDTEL DEEDMQKITS GCKSKTQITW PKLGTLLCTN PLEKFGPIGP
QTDTNLPVFH KLVETRWRDL NQTFNHKGQA EEISPLQLEL LALMGSYKDL YYPETCPVKQ
GPHVRSAYCL HVLNHVLKAN SQVLAHNSQL KEQKSRTKAG AEPQDELRDQ GLTRPKVLIL
VPFRGSALQV VHTLISLLET KGKKVMVSNK KKFKEEFGED EDEKPPNLQR PDDYNAIFTG
NVDDHFRIGV SILKGSMRLY APFYSSDIII TSPLGLRTVL GAEGERKRDF DFLSSIELLV
VDQADVFLMQ NWEHVLHVMK HMNLQPLDSH GVDFSRVRMW NLNNWARYYR QTLVFSSIQD
PQINNILTKH CANYRGQIVI KNIPKTGSIC QVLVQLPHVF QMFSSASFID HDARFQFFID
KVLPQYKDSV MSHTLIYIPS YFDYVRLRNY MKKEEMNFAS VCEYSSKSEV SRARHFFQKG
EKQFMLFTER FHFYKRYTIK GIQNLIFYGL PSFPHFYSEV CNMLATATQG EEASWTCTAL
YSRYDAHKLA AITGAQRAGQ MLNSNKAVHL FVTGGEDKNV
//
