ID A0A3P9BPG3_9CICH Unreviewed; 337 AA.
AC A0A3P9BPG3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Sodium/bile acid cotransporter {ECO:0000256|PIRNR:PIRNR026166};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005011809.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005011809.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Does not show transport activity towards bile acids or
CC steroid sulfates. {ECO:0000256|PIRNR:PIRNR026166}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR026166}.
CC Endoplasmic reticulum membrane {ECO:0000256|PIRNR:PIRNR026166}. Golgi
CC apparatus membrane {ECO:0000256|ARBA:ARBA00004394}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000256|ARBA:ARBA00006528,
CC ECO:0000256|PIRNR:PIRNR026166}.
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DR AlphaFoldDB; A0A3P9BPG3; -.
DR Ensembl; ENSMZET00005012215.1; ENSMZEP00005011809.1; ENSMZEG00005008847.1.
DR GeneTree; ENSGT00390000011932; -.
DR Proteomes; UP000265160; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR016833; Put_Na-Bile_cotransptr.
DR PANTHER; PTHR18640:SF5; SODIUM_BILE ACID COTRANSPORTER 7; 1.
DR PANTHER; PTHR18640; SOLUTE CARRIER FAMILY 10 MEMBER 7; 1.
DR Pfam; PF13593; SBF_like; 1.
DR PIRSF; PIRSF026166; UCP026166; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|PIRNR:PIRNR026166};
KW Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR026166};
KW Ion transport {ECO:0000256|PIRNR:PIRNR026166};
KW Membrane {ECO:0000256|PIRNR:PIRNR026166, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Sodium {ECO:0000256|PIRNR:PIRNR026166};
KW Sodium transport {ECO:0000256|PIRNR:PIRNR026166};
KW Symport {ECO:0000256|PIRNR:PIRNR026166};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|PIRNR:PIRNR026166}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 41..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 337 AA; 36822 MW; F32606F22E99B726 CRC64;
MGLVARIRKE WFIVGIVLVI LSAKLQPSIG VKGGPLKPEV TVAYIAVSLI FFNSGLSLKT
EELTSALLHV RLHLFVQSFT LIFFPLAVWL LLKVLSLTAI DQWLLRGLQT VSCMPPPVSS
AVILTKAVGG NEAAAIFNSA FGSFLGIVVT PLLLLLFLGS SSSVPFSSIF SQLFMTVVVP
LILGQVCRGF LREFLERQKP PFGAISSAVL LMIIYTTFCE TFSNPSIELD PTSLLLVGLI
IFSIQISFML LTFAFSTRPG SRFSAADTVA IMFCSTHKSL TLGIPMLKIV FEGYEHLSLI
SVPLLIYHPA QILLGSVLVP TIRSWMTSRQ KSSLLLR
//
