ID A0A3P9BQ78_9CICH Unreviewed; 810 AA.
AC A0A3P9BQ78;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Mucosa-associated lymphoid tissue lymphoma translocation protein 1 {ECO:0000313|Ensembl:ENSMZEP00005012095.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005012095.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005012095.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005012095.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9BQ78; -.
DR Ensembl; ENSMZET00005012522.1; ENSMZEP00005012095.1; ENSMZEG00005009058.1.
DR GeneTree; ENSGT00390000018044; -.
DR Proteomes; UP000265160; LG23.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.3360; -; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR041077; MALT1_Ig.
DR InterPro; IPR033540; MALT1_IG-like_dom_sf.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR001309; Pept_C14_p20.
DR PANTHER; PTHR22576:SF27; MALT PARACASPASE 2; 1.
DR PANTHER; PTHR22576; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF18703; MALT1_Ig; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 106..182
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 206..292
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 321..448
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT REGION 738..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 810 AA; 90233 MW; F4AD97DA3DEB6419 CRC64;
MEEWKRSIGT LSDEILIKLA KMLDNSTCGW RQLANAVSEQ PKFRCSEREL TSCSLQVLTA
AGSPARTMLT LLAERSCSLD FLLHSLRKME HQEAVQFLTT AVAEQIQITV QPQSQEAAPG
SNVVLTCRAS GPPGLGYQWF KGKQEILGES GNSSELVLCP LSPTHQGHYI CRISHGEKFV
FSKWAQVRLI ISAGSSSFCC SSSLFPGSVS GLHIIQRPQS QAASEGDTLV LECTAEGNPP
AQYEWYHNKV PMPQQKTSSL RIPCVTTAHR GEYTCKVFNL YHEVWSSTAT VTIGEPLQIP
SLTFVDLWWI SLLILFLSTA TDKVALLIGN MNYIYHTQLC APISDVHELT NLLRQLDFKV
VSLLDLNWQE MHSAVTEFLL LLDKGVYGLL YFAGHGYENY GNSFMVPIDA PVSYTSEHCL
CVQNILTKMQ EKKTGLNVFL LDMCRKRNPH DDVIVQPGLL KVTANIVFGY ATCVDAEAYE
VKREDVSNGI FINFLKQRVC EDEKVTVMLD RVAEDMGRCV ITRGRQALEL RSNLSERRSL
TDRIQVSQCS ASSSARNLQW AIAHVLPESR YLQFDCGVKV QLGFAAEFSN VMVIYTRILD
KPDEIVSCSA QLTDFPEDVD IDLKKSNQES LLEAGCLSLI KEELPSPETH SLYTHIRSLQ
RLKRELTFTI CLHYTYSNMD EEVQERQQVT VGKPLVSKLN LHEPRAAHVS SASSSFSLDS
FNVPGCSSFG EDLSLTGTAS NTRSHHAQSA SVSFTGGSPT SPRSANVPEE TDSPEILDNP
RPLVASKSLP HSKVNDSNYK FSDMYNFHSY
//
