ID A0A3P9BRD4_9CICH Unreviewed; 1172 AA.
AC A0A3P9BRD4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=WD repeat-containing protein 35 {ECO:0000256|PIRNR:PIRNR037536};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005012484.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005012484.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005012484.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|PIRNR:PIRNR037536}. Cytoplasm,
CC cytoskeleton, cilium basal body {ECO:0000256|PIRNR:PIRNR037536}.
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DR AlphaFoldDB; A0A3P9BRD4; -.
DR Ensembl; ENSMZET00005012923.1; ENSMZEP00005012484.1; ENSMZEG00005009317.1.
DR GeneTree; ENSGT00940000155745; -.
DR Proteomes; UP000265160; LG19.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0036064; C:ciliary basal body; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030991; C:intraciliary transport particle A; IEA:UniProtKB-UniRule.
DR GO; GO:0060271; P:cilium assembly; IEA:InterPro.
DR GO; GO:0035721; P:intraciliary retrograde transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.470; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039857; Ift122/121.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR017233; WDR35.
DR PANTHER; PTHR12764:SF5; LD29485P; 1.
DR PANTHER; PTHR12764; WD REPEAT DOMAIN-RELATED; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 2.
DR PIRSF; PIRSF037536; WD_repeat_p35; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|PIRNR:PIRNR037536};
KW Cilium {ECO:0000256|PIRNR:PIRNR037536};
KW Cilium biogenesis/degradation {ECO:0000256|PIRNR:PIRNR037536};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037536};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR037536};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 67..98
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 135..195
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
SQ SEQUENCE 1172 AA; 132894 MW; 9BEA2925B7128A76 CRC64;
MFIYLSKKIA IPNNIHLKCV SWNKDQGFIA CGGDDGLLRV LKLETQTDDA KLKGLAAPSN
LSMNQTLEGH SGAVQVVTWN EQHEKLTTSD QNGLIIVWML YRGAWYEEMI NNRNKSVVRS
MSWNADGQKI CIVYEDGAVI VGSVDGNRIW GKELKGSQLA HVAWSPDSKI LLFGMANGEV
HIYDNQGNFI MKMTISCLVN VTGAVSIAGI HWYAGSGGYV EPDCPCLAIC FDNGRCQIMR
YESDENPVCI DTLMNVVSIQ WNHCGSVLAV AGSLRGAMEK EFNVVQFYTP FGEHLRTLKV
PGKQMSGVAW EGGGLRIALA VESFIYFANI RPDYKWGYCC STVVYAYTKP ERQEYCVVFW
DTKNNEKFVK YVKSLMSITT SGDFCILASK ADDTQPQYVL ILFNSIGTPL DSKYIDIDPM
FVTMTKTHVI AASKEAFYMW QYRVAKKLTA LEINQVTRTK KEGRERVYHI DSTPSGASDT
SPDFTKAFTA TRDPICCITA TDKTLIVGRE SGTLHRYSLP NVVLVQKYTL NNRAHYLSLN
CNSSRLAIID IAGIMTLLDL EVHTSTDNGT GNQPSTGDPS KFERKDVWDM KWANDNPDLF
AMMEKTRMYV FRNLDPEEPI QTSGYICNFE DLEIKSVLLD EIMKDPERPN KDNLINFEIR
SLRDSRALIE KVGIEEASQF IEDNPHPRLW RLLAEAALQK LDLKTAEQAF VRCKDYQGIE
FVKRLGNLQS EPMKQAEVAA YFSRFEEAER MYLDMDRRDL AISLRIKLGD WFKVLALLKS
GSGDSDDALL EQANNAIGDY YADRQKWVSA VQYYIKGRNQ ERLAECYYML EDYDGLERLT
AALPENHKLL QEIGQMFATV GMCEQAVNAY LKCNQPKAAV DTCVHLNQWN KAVELARTHN
MKEIKSLLSK YASHLLEKNK TLEAVELYRK AHHFLDAAKL MFKIADEEAK KRTRPLRVKK
LYVLAAHLVE NYHKQVKTSQ QSKGKGKKTE ATHALASLLE EDATSADNRI VDNAWRGAEA
YHFFLLAQRQ LYDGYLENAM RTALHLREYE DVIPPVDIYS LLAVCSAANR AFGTCSQAFI
KLESLESLDP EQRQAYEDLA LEIFTKHSPK DSRMIEWNAS SEGMEERFRT CIVTGLPVQE
YSCWICSVCK HCAHDQEISK YNCCPLCHTP IL
//
