ID A0A3P9BRM9_9CICH Unreviewed; 1057 AA.
AC A0A3P9BRM9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=FERM, ARH/RhoGEF and pleckstrin domain protein 2 {ECO:0000313|Ensembl:ENSMZEP00005012595.1};
GN Name=FARP2 {ECO:0000313|Ensembl:ENSMZEP00005012595.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005012595.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005012595.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005012595.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_004552921.1; XM_004552864.3.
DR AlphaFoldDB; A0A3P9BRM9; -.
DR STRING; 106582.ENSMZEP00005012595; -.
DR Ensembl; ENSMZET00005013039.1; ENSMZEP00005012595.1; ENSMZEG00005009451.1.
DR GeneID; 101483569; -.
DR KEGG; mze:101483569; -.
DR CTD; 9855; -.
DR GeneTree; ENSGT00940000158642; -.
DR OrthoDB; 2876516at2759; -.
DR Proteomes; UP000265160; LG23.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 50..330
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 546..737
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 766..863
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 940..1037
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 365..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 648..678
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 424..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..469
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..913
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1057 AA; 121569 MW; B949E9BFC130EE89 CRC64;
MGEIEGSYRV LQTPGTRLGA QFNAGISTLE PGQSLSGNMV NRRISQGRGI QIRVQGLDDS
QEFFDIEPKA LGQILLSEVF HRGNLIESDY FGLEFQNMQM NWVWLEPTKP ISKQVRRPAN
TLFRLSVKFF PPDPGQLQEE YTRYLFSLQM KRDLMEGRLI CTENTGALLA SHLVQSEIGD
YDDTADREYL RINKLLPYQE KVQERIMELH RRHLGQTPAE SDFQILEIAR KLEMYGVRFH
PAADREGTKI NLSVAHMGLQ VFQGHTKINT FNWSKIRKLS FKRKRFLIKL HPEVHGPHQD
TLEFLMGSRD QCKVFWKICV EYHSFFRLFD HPQPKSKAVL FTRGSSFRYS GRTQKQLVEY
VRENGAKRTP YQRRNSKVRM SARSLATDVP KQSFSFNDSL RFPGSSSSAA VTFQSMHIPS
VFPLTERQPQ PQPLTALSQS PAPSQQQQLQ SPLQATRPPS PPKEEPIKPT SPSPYAFQDS
VVDSPQLSPV ASKGPLCLSP SFQMSNLSLP GQTPSPLQSP ILSEVGSNAR LEEEEEGRRK
RYPTDKAYFI AKEILTTERT YLKDLEVITV WFRSAVIKEN AMPEGLMTLL FSNIDPIYEF
HRGFLKELDQ RLALWEGRSN AHVKGDYQRI GDVMLKNMCA LKEFTSYLQK HDEVLTELEK
ASKRLKKLET VYKEFELQKV CYLPLNTFLL KPIQRLMHYK LILERLCKHY SPAHRDYDDC
KEALKEVAEI ATQLQSSLIR LENFQKLTEL QRDLIGIENL TAPGREFIRE GCLYKLTKKG
LQQRMFFLFS DMLLYTSKGV TATNQFKVHG QLPLHGMIVE ESENEWSVPH CFTIYSAQRT
IVVAASSKVE MGKWIEDLNL AIDMAKKSQE KSSIFLDAGL SDRSNRSSDE VSLEQESEDD
MNSSRTSLDK QTHHRANTTM HVCWHRNTSV SMSDHSLAVE NQLSGYLLRK FKNSNGWQKL
WVVFTNFCLF FYKTHQDDFP LASLPLLGYT VSTPEESDSI HKEYVFKLQF KSHVYFFRAE
SEYTFERWME VIKSAASTAG RMSLLIPKGG PMEINGN
//
