ID A0A3P9BS50_9CICH Unreviewed; 1473 AA.
AC A0A3P9BS50;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=GTPase activating protein and VPS9 domains 1 {ECO:0000313|Ensembl:ENSMZEP00005012461.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005012461.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005012461.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005012461.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GAPVD1 family.
CC {ECO:0000256|ARBA:ARBA00008489}.
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DR STRING; 106582.ENSMZEP00005012461; -.
DR Ensembl; ENSMZET00005012900.1; ENSMZEP00005012461.1; ENSMZEG00005009310.1.
DR GeneTree; ENSGT00940000156611; -.
DR Proteomes; UP000265160; LG12.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd05129; RasGAP_RAP6; 1.
DR Gene3D; 1.10.246.120; -; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR041545; DUF5601.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR23101:SF25; GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR Pfam; PF18151; DUF5601; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00167; VPS9; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 3: Inferred from homology;
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 144..352
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1333..1473
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REGION 452..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1010..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..886
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..923
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..991
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1010..1025
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1473 AA; 163639 MW; FDC427F38906FD15 CRC64;
MVKPDIHTLA HHLKQERLYV ASEKQLIQRL NSDVLKTAER LYRAAWIAKQ QRINLDRLIL
TSAEASPAEC CQHAKMLEDT QFIDGYKTLG FHETIYGEFL ARLRDNPRLV ASCLVAGERL
IQEHTQGAIY TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI
LFKLFSEGLY SAKLFLTATL HEPIMQLLVE DEDHLETDPA KVTERLTPAQ QERYGEKGSE
GYKQRVQAAV EANEAKLVAL VNKFIGYLKQ NTYCFPHSLR WIVSQMYKTL SCVERLEVGE
VRTMCTDLLL TCFICPAIVN PEQYGIISDA PINEVARFNL MQVGQLLQQL AMADDDADPR
RKSSLSKFDK SCVAAFLDVV IGGRAVETPP MSSMNLLEGL SRTAVYVTHN QLLSLVEFVR
GLMAGDHLRE EEHMALETLL ANVPQSRTVK SNSLELTPSN TPQLSPATTP ANKKNRLPIG
QHLAAITSWD PTTTTLSAHI PLVTPFASAR SRSRSNIAQE GEAEASSQES LQELVPEEVL
VISLGTGPQT VPGMMSENEV LNQMADGAQV DGHADDTKLH GKPDKTLRFS LCSDNLEGIS
EGPSNRSNSV SSLDLEGESV SELGAGPSGS NGVEALQLLE HEQATTQDNL DDKLRKFEIR
DMMGLTDDRD ISETVSETWS TDVLGSDFDP NMDEDRLQEI AGAAAENMLG SLLCLPGTGS
VLLDPYGSTI SETTSEAWSV EVLPSDSEAA DLKQEERLQE LESCSGVGST SDDTEVREVS
SRPSTPGLSV VSGISATSED IPNKIEDLRS ECSSDFGGKD SVTSPDGEES GHGAHHLTSP
PSQVDSLLAM FDPLSTAEGS STGTIVRPKV HYARPPHPPP DPPIPEASAL GQETRHSLFT
PHCLAQSELE HTKQRHSFPD RLVRSRSSDI VCPGRRPTSD PGLNRRVAVE ERDPAGAFAL
GPSSSPSKDS LKGEVEDRKD SDDEKSDRNR PWWKKRFVPA IPKAPIAAFR KRDKQEKDEV
VHNIPQDDPL LRSSTQAQAA EDILDKYRNI KRTSPSDGAT AGASYDGAGD LCVEDNVHDA
QREDTLQNIS ADDLPDSASQ TAQQHETKFS FSDAKKKLRL ALCSADSVAL PIMAPATTRN
GLPDHMDPEE NEIVCFLKIQ LAEAINLQDK NLMAQIQETT RCVSRFDART CRKLLAAIAE
DYRKRAPYIA YLTRCRQGLQ TSQAHLERLL QRVLRDKEVA NRYFTTVCVR LLLEHMESKM
LDFIKAFQGC TAADDKTAAV EDFLRYLYGA MARDAIWQYA SEDQLQDAQM AIERSVMNRI
FKLAFYPNQD GDILRDQLFH EHIQRLSKVV TANHKALQIP EVYLKEAPWP SAQSEIKSIN
AYKTPRDKVQ CILRMCSTIM NLLSLANEDS VPGADDFVPV LVFVLIRANP PCLLSTVQYI
NNFYASRLSG EECYWWMQFT AAGEFIKTID DRK
//
