ID A0A3P9BSE5_9CICH Unreviewed; 637 AA.
AC A0A3P9BSE5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Carnitine O-acetyltransferase {ECO:0000313|Ensembl:ENSMZEP00005012556.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005012556.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005012556.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005012556.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232}.
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DR RefSeq; XP_004564711.1; XM_004564654.3.
DR AlphaFoldDB; A0A3P9BSE5; -.
DR STRING; 106582.ENSMZEP00005012556; -.
DR Ensembl; ENSMZET00005013000.1; ENSMZEP00005012556.1; ENSMZEG00005009438.1.
DR GeneID; 101472869; -.
DR KEGG; mze:101472869; -.
DR GeneTree; ENSGT01060000248556; -.
DR OrthoDB; 3970920at2759; -.
DR Proteomes; UP000265160; LG7.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589:SF50; CARNITINE O-ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 49..616
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 351
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 637 AA; 72193 MW; B5FD40A007867DE1 CRC64;
MLRILNRIIV NVGMMNSYGL VKSCRLVNSA SDTLMGGRYL NHQKGLPRLP VPPLRETCER
YLSCLEPLVT EDELKHIKRL MKEFLKEGGD GEKLQRSLER KACTTDNWLA DYGIQINYLD
SRESLLISNG GFVLPKMDFT DKQGQIRCAA KVIKAVLDFK TMIEDETLPV QYMRGEPLCM
MQYFRALSSC RVPGQKTDSL VFHAKNSNPR HITVAQNSQF FTVEVYHSDG TPITADQLCV
QLERICNSSL ETNTEHVGIL TTLHRDTWYK YYNKLVQDPS NKKSVSAIER SICVLCLDKA
MPRTYEKYSR FEPVQVLHGG GTQWNSANRW FDKSLQFIVG EDGTCGFTML HAIIDGTPCM
ALSDYITSSM KKPQMMESPV ALLPMPQKLH FNITPDIKTA IEEAKQSVDK HAQDLDLRVL
VFNHFGKQIP KAHQISPDAF IQMAIQLAYY RIHQQCCASY EAASMRLFRK GRLGVILSTS
SASAAFVKSF DDPKKQNSEK RNLLENAIKV HMWNTNMEIR GRTTFGHFLG LKVQAIENNI
PMPDIYTDTS LNKAFNFLLS TSQVAFKAAC LGSAVPEKLN SYDFCYSVTS DNFTFVVSAW
KSCKENNVVR LIQTLEDTLV DMKMLLEETK LEPDGST
//
