ID A0A3P9BSR1_9CICH Unreviewed; 609 AA.
AC A0A3P9BSR1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Sushi domain-containing protein 4 {ECO:0000313|Ensembl:ENSMZEP00005012661.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005012661.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005012661.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005012661.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR RefSeq; XP_004540815.1; XM_004540758.2.
DR AlphaFoldDB; A0A3P9BSR1; -.
DR Ensembl; ENSMZET00005013105.1; ENSMZEP00005012661.1; ENSMZEG00005009514.1.
DR GeneID; 101486451; -.
DR KEGG; mze:101486451; -.
DR GeneTree; ENSGT00940000157120; -.
DR OrthoDB; 3659826at2759; -.
DR Proteomes; UP000265160; LG19.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 6.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 6.
DR InterPro; IPR042866; SUSD6.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR46839; SUSHI DOMAIN-CONTAINING PROTEIN 6; 1.
DR PANTHER; PTHR46839:SF1; SUSHI DOMAIN-CONTAINING PROTEIN 6 PRECURSOR; 1.
DR Pfam; PF00084; Sushi; 6.
DR SMART; SM00032; CCP; 6.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 6.
DR PROSITE; PS50923; SUSHI; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..38
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 39..609
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018199547"
FT TRANSMEM 438..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..101
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 116..166
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 167..229
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 231..294
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 296..358
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 373..423
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 521..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..609
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 72..99
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 200..227
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 329..356
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 609 AA; 66328 MW; 0C1069FF5CC25AFA CRC64;
MCNGMIESIS KAFWAHTSAT KRSFLLLLFL IVVSTGQGSG CVRPYMVQNS WVNLTETNRG
SFPVGTVLQY SCDPGYLPDG PNILTCTAVG RWSSEPPRCI RSGACLPLSK PDNGGYTCHP
SPCRLFAHGT VIEFFCNEGF MLSGDYNYLT CQDGEWDGPM EISCVSQGCI RPSMVQHGSA
NLTDSNRSLF PVGTVLHYGC DPGYLPAGPT SLTCTKLGDW SSEPPRCIRS DVCQPPYQPK
NGSYTCHPSP CKRFSHGTVI QYFCDDGYIL KGDYKFITCQ YGKWDTVMPV SCVIEQGCRR
PSMVQHGSAN LTDTSRSFFP VGTALQYTCN PGYLLDGPRT VTCTTLGHWS SESPRCIHSD
VCQRPYQPEN GGFTCHPFPC QRLSHGTVIE YFCNEGYILK GDYKYLTCQY GEWDSQMKLS
CIMKQDHSPT LPLGMPTLSI VASTACSVAF ILLLVVLFVL LQPKLKSLHR RDQGVSGQPV
SIMVEGVQVT LPSYEEAVSS SGASALSSES RVQIVLSEGQ HATAPEAGPS RPSSLKQQQQ
QSEMAVVHPV PPSSSSSSPS SSTWALEHAG AAAGTSSSQR RPSRGSDHHS LSLDSEMDYS
DDIPLLKEA
//
