ID A0A3P9BTH3_9CICH Unreviewed; 662 AA.
AC A0A3P9BTH3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=ADP-ribosylation factor-binding protein GGA1 {ECO:0000313|Ensembl:ENSMZEP00005013255.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005013255.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005013255.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005013255.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004150}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GGA protein family.
CC {ECO:0000256|ARBA:ARBA00008099}.
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DR RefSeq; XP_004538966.1; XM_004538909.1.
DR AlphaFoldDB; A0A3P9BTH3; -.
DR STRING; 106582.ENSMZEP00005013255; -.
DR Ensembl; ENSMZET00005013707.1; ENSMZEP00005013255.1; ENSMZEG00005009956.1.
DR GeneID; 101484165; -.
DR KEGG; mze:101484165; -.
DR GeneTree; ENSGT00940000156448; -.
DR OrthoDB; 2917368at2759; -.
DR Proteomes; UP000265160; LG6.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd14239; GAT_GGA1_GGA2; 1.
DR CDD; cd17009; VHS_GGA1; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.60.40.1230; -; 1.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR008153; GAE_dom.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR027422; GGA1-3.
DR InterPro; IPR041198; GGA_N-GAT.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45905:SF4; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1; 1.
DR PANTHER; PTHR45905; GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF18308; GGA_N-GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50180; GAE; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 19..149
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 173..300
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT DOMAIN 533..654
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 435..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 662 AA; 72585 MW; F8C6FFC55913E088 CRC64;
MAAAAPPDEA SLQSRINKAT NPLNKEIDWD SIKGFCDQLE NEPEGPQLAT RLLAHKIQSP
QEWEAMQALT VLETCMKNCG KRFHSEVGKF RFLNELIKVV SPKYLGARAP EAVKKKVLEM
IYSWTVRLPD ETKILEAYQM LKKQGIVKQD PVLPVDKPLP PPPPRAKSAI FEDEEKSKTL
SRLLNSTHPE DLRAANKLIK EMVQEDQKRV EKVSKRVNAI QEVKESVSLL SQLLEGYNKE
SCSQSNQELI KDLYNRCEKM RPTLFRLASD TEDNDEALAD ILQANDSLTQ VINQYRQLVK
GEDVSKDVIN SSLQPGNSSS ALVDLTGLNI SANTAPSNTD SSSLQLLTQN MGLSLLDDEL
MSLGLNVTEN GDSQNTFQSS DITEVSTQSA PASVLLPAVV QKPRAPPVEG ATAPPKAMEE
LDLLGKALLQ QSLPPESQQV KWDKLQPQSR VPLRDLQAKS SSKPTPAATS TSTSSSATAP
GASSVIHSEQ SDAVLLSNLT LTVTDKASLP TADTYDSISL ADVTVPLEII KPSTLLPVTV
FDKHSLRVLF TFARDCPPSR PDVLVVIISM LSSAPIPVTN IRFQAAVPRV MKVKLQPPSS
TELPAFNPIL SPAAITQILL LANPHKEKVR LRYKLTFNLG DKSHDESGDV DQFPPPNTWG
NL
//
