ID A0A3P9BUU0_9CICH Unreviewed; 1255 AA.
AC A0A3P9BUU0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Dynactin subunit 1 {ECO:0000256|ARBA:ARBA00016574};
GN Name=DCTN1 {ECO:0000313|Ensembl:ENSMZEP00005013687.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005013687.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005013687.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005013687.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynactin 150 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00011010}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P9BUU0; -.
DR Ensembl; ENSMZET00005014155.1; ENSMZEP00005013687.1; ENSMZEG00005010155.1.
DR GeneTree; ENSGT00940000155378; -.
DR Proteomes; UP000265160; LG19.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1170.10; -; 1.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR022157; Dynactin.
DR PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1.
DR PANTHER; PTHR18916:SF6; DYNACTIN SUBUNIT 1; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF12455; Dynactin; 1.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 50..92
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 198..528
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 934..1025
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1076..1103
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1162..1189
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1255 AA; 139661 MW; 6492332351393BCC CRC64;
MSHTRRNTYT RTTSSGSSRM SSDGGGRPVK VGSLVEVIGK GQRGTVAYIG TTLFASGKWV
GVILDEAKGK NDGTVQGKRY FTCEENHGIF VRQSQIQLVD DGADTTSPET PEPGTGKVPK
REILESAKSA KLTTARRPKQ PSRPAGGKGA ASGSASASAG EMSSSEPSTP AQTPLAAPVI
PTLHSPGNPP APIPSKEEEA LRNQVKDLEE KLETLKMKRT EDKAKLKELE KHKIQLEQLQ
EWKTKMQEQQ AELQKQLKEA KREAKEALEA KERYMEEMSD TADAIEMATL DKEMAEERAE
SLQLEVDSLK EKVDELTMDL EILKHEIEEK GSDGAASSYH VKQLEEQNSR LKEALVRMRD
LSASEKQEHV KLQKQMEKKN VELDCLRSQK EKLQEEMKAA EKTIDELKEQ VDAALGAEEM
VETLTERNLD LEEKVRELRE TVTDLEAINE MNDELQENAR ETELELREML DLGAARVREA
EKRVEAAQET VADYQQTIKK YRELTAHLQE VNRELTSQQE ASAELQQQPP AEMFDFKIKF
AETKAYAKAI EMELRKMEVG QANRHVSLLT SFMPESFLRH GGDHDCILVL LLIPRLICKA
ELISKQAQEK FDLNENCVER AGLKGALGEQ LSFAGGLVYS LSLLQATLHK YEQALSQCSV
EVYKKIGSLY PEMSVHERSL DFLIDLLHKD QLDETVNVEP LTKAIKYYQH LYSIHLADQN
EDCTMQLADH IRFTQSALDC MAVEVGRLRA FLHAGQEKAD LAVLLKDLET SCSDIRQFCK
KIRRRMPGTD APGIPAALSF GQQVSDTLSD CRKHLTWVVA VLQEVAAAGA QMMSPLGEQE
GLSAVKLEDV AFKAGEQIYG SQGANPYEYL RQSCSIVIAT MNKMATAMQE GEYDSEKPQN
KNPPPVDVRA AALRAEITDA EGLGLKLEDR ETVIKELKKS LKIKGEELSE ANVRLSLLEK
KLDSSSKDAD ERVEKIQTRL DEAQTLLKKK EKEFEETMDA LQADIDQLEA EKAELKQRIN
SQSKMTIDGL RGTGPSGIAS IVTGMAGEEQ KANMVSGVGS GSGVQVIDSP LLTQQIEAQR
LCIKHLKNEN NRLKAEKMRA QLASLPPLNV TKLPSKDGRP EVLSSALYRK TDQLLETLLQ
MSANVKVVDI TGKSPVTPGA QLLEQTARLQ SLNDTLDRLK DEVAEHVVNL QPGARVSSDF
ATFPSTSFVK VKEEKKGDTV LVGRVMVPCP RGQEQVHRLV LSQSELWRVH SLLRT
//
