ID A0A3P9BUW4_9CICH Unreviewed; 1702 AA.
AC A0A3P9BUW4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Signal induced proliferation associated 1 like 2 {ECO:0000313|Ensembl:ENSMZEP00005013426.1};
GN Name=SIPA1L2 {ECO:0000313|Ensembl:ENSMZEP00005013426.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005013426.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005013426.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005013426.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSMZET00005013880.1; ENSMZEP00005013426.1; ENSMZEG00005010066.1.
DR GeneTree; ENSGT00940000157388; -.
DR Proteomes; UP000265160; LG13.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR021818; SIPA1L_C.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF7; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF11881; SPAR_C; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 604..821
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 959..1035
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 42..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1111..1270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1354..1373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1390..1414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1428..1450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1503..1522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1531..1553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1638..1686
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 392..406
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1127..1172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1238..1264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1354..1369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1702 AA; 187533 MW; 248A3F9132837C45 CRC64;
MSILSPVTAN KSNLVGIVGG PEEYSRVMQS EELFSRKLKA LSDSMGPPAS SMQGKPDGAG
KTNGTPAMPK MGVRARVTEW PPRKDGWDGR PSPNYQSVIP VFQNGQQEHT VEILEQGEAV
CLEVDYTDKY TLSDFLCHSP LKGLHPIRQR SNSDVTISDI DSEDVMDQNA VNPNTGASLH
REYGSTSSID RQGLTGDGFF TMLKGYRVET LDHRSIPPLG FPELLRCDAS LSPSLQTAAQ
IARGEIVHIP GYDYIDSSLL YSREREKSFM RRLKSESSET SLFRKLRPIK SESDALRLSI
EDDRRPLSFQ KCFAHYDVQS VLFNISEAVA SRANLSQRKN TTTGASAASA GAGAGGVSVV
GGGAGPGAGA DGGAAGCNSA NTPMFESPLG SREDLNPKEN LDADEGDGKS NSLVLSCPHF
RNEIGGESER KISLSRANSV NYSGLSESCS FESSLSSHCT NAGVSVLEVP RENQPIHREK
VKRYIIEHID LGAYYYHKFF YGREHQNYFG VDDHLGPVAV SIRREKLDDG RDKEGTQYNY
RVTFRTSQLT TLRGAILEDA IPSTARHGTA RGLPLKEVLE YVIPELNIQC LRLAMNSPKV
AEQLLKLDEQ GLSFQHKVGV LYCKAGQSTE EEMYNNESAG PALDEFLDLL GQRVRLKGFT
KYRAQLDNKT DSTGTHSLYT TYKDYELMFH VSTMLPYTPN NRQQLLRKRH IGNDIVTIVF
QEPGALPFTP KNIRSHFQHV FVIVKVHNPC TDNVCYSVAV SRSKDVPPFG PPIPKSVTFP
KSAVFRDFLL AKVINGENAA HKSEKFRAMA TRTRQEYLKD LAENFVSTAT IDSAVKFSFI
SLGGKKKEKV KPRKDAHLFS VGAITWSVRA RDFGQSLDFD CLLGISNEFI VLIEEESKNV
IFNCSCRDVI GWTSGIMSIK IFYERGECVM LSAHDNCGED IREMVQRLEI ATRGCETTEM
TLRRNGLGQL GFHVNFEGIV ADVEPFGFAW KAGLRQGSRL VEICKVAVAT LTHEQMIDLL
RTSVTVKVVI IQPYEDGTPR RGCSELYRIP MVEYKVDSEG TPCEYKTPFR RNTTWHRVPT
AAGALSRGSP TQGPDRLQCQ QILQQHQAAI PRSTSFDRKL PDGSRTVQDM ENPQVTSCNK
GDQHYRSSPS NQSSSSDPGP CGSSTWSQQP GYDGCPSPIL HERVGDIQGG DGEIHREREP
TLERTRSAEA KWHIPSTKIL NPLKQREGGK DSPNKLSRAG DKNSSHSSSN TLSSNASSNS
DDKHFGSGDL MDPEMLGLTY IKGASTDSGI DTNPCVAPGA RVLLQGRVGE QGHPWVSEHH
EDGASEEDHG KMYLPQGYAS AILSSHVTEG SIGDLSEISS HSSGSHHSGS PLARGARYCM
SADSSKVYTI PQTSSSGPEL VQGSGLGPGS EACGQARTQS SCKFTVGAKA TDDDDDDAAH
STEEPPNISE CGGAESLLTF LLTMLSERSR QLYAQEAACR LQATERDGKS LQRLSKEEYV
KMMLPDSPPG EDRSRKVSAV DSLSPRRSLY RTLSDESVSS NRKGSSYASS HSSMLDQAMP
NDILFSTTPP YHSTLPPRMI HNQGASNLRN QRVASFCTMT DMQRVEALQI SRELTRRVVE
AEGAALGADS PSTLTGKVNQ LEVILRQLQH DLRKEKEDKA MLQEEVQHLR QDNMRLQEES
QTAAAQLRKF TEWFFHTIDK KP
//
