ID A0A3P9BV93_9CICH Unreviewed; 1614 AA.
AC A0A3P9BV93;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Kinesin family member 26B {ECO:0000313|Ensembl:ENSMZEP00005013863.1};
GN Name=KIF26B {ECO:0000313|Ensembl:ENSMZEP00005013863.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005013863.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005013863.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005013863.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR STRING; 106582.ENSMZEP00005013863; -.
DR Ensembl; ENSMZET00005014332.1; ENSMZEP00005013863.1; ENSMZEG00005010419.1.
DR GeneTree; ENSGT00940000156992; -.
DR Proteomes; UP000265160; LG1.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00106; KISc; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21608:SF8; KINESIN-LIKE PROTEIN KIF26B; 1.
DR PANTHER; PTHR21608; UNCHARACTERIZED; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 1..365
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 367..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 813..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1093..1158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1201..1311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1330..1381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1398..1472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1527..1554
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 384..407
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..830
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1216..1309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1330..1354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1400..1434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1447..1467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 99..106
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1614 AA; 172097 MW; 9629FB02C59684C3 CRC64;
MGVMVRVCPV SQSDAAESSS FLKVDPRKKQ ITIMDPSANQ TQSAASQKRA GANQVPPKMF
TFDAAFPPDA SQAEVCAGTV AEVIQSVVNG ADGCVFCFGH SKLGKSYTMI GRDDSLQTLG
IIPCAISWLF KLINERKEKT GARFSVRVSA VEVWGKEENL KDLLSEVATG SLQDGQSPGV
YLCEDPICGM QLQNQSELRA PTPEKAAWFL DAAIAARHSS QRSNTTEEEH RNSHMLFTLH
IYQYRMEKTG KGGMSGGRSR LHLLDLGSCD VKVLGGGGGG KSRENSSPSS APLCLSLSAL
GNVILALVNG SKHIPYKDRK LTMLLRESLG NMNCRTTMIA HISASPRDFS ETLSTIQIAS
RVLRMKKKKT KQYTSSSSGG ESSCEEGRMR RPTHLRPFHH RGDPDSDLPL LRLSSDPDEY
SSSEQSCDTV IYVGPNGAAV SDRELTDNEG PPEFVPIIPA LLRGKTSEQK EGAECLKCNT
FAELQERLDC IDGSEEVAKF PFEEAPAIKQ GVKQEACPSS SVPAAAPAPA PPAVLDTEAK
TGSIIIRNND DASVHILHVL YVNVHENLNV AGGNCEGKSR PLGSPRLGIA SLTKTSEYRP
PSSPSQRCKV YTQKGVIPAI LAADSGRSST ESLLSRSSPA GMSPQVREPT PSLSASLGSA
ETLCDDDVPP IPLDSKDAAS AVTLGPLVLG DDELVYTVVT GGEEDLDITA LIENEGLAGR
PVSIISFNSD CGSAAALATG SQPICTALDG VVEDHMLVGP AASSGVSDVV AMAEVSATLI
LRTEGESLAT GMSNCGSPNS SWVSDLSAGS EADQSLHSFS QSQSQQGEAL ADPDPNFGIE
TLDGYENGGT PRRGSLEGEM VLSENQSDKG TPTKERLRKL PPSMAKTNIQ ILAGPGNMAP
FKTNILVHPC AAVKPMVVQE ATILSSPTKA NFMKDPVKSS AAFIASISSE MSFEDPWLKR
GTEEGKSKEL VCERKLEKRE AEHSKGHSID KANGGGGDRG SSSSGGEVVS SPDSFKRVVD
GCEMVAVVAQ GECLTSIYNP DIHRTASLPR GWHRVNRHDG LDNGSEYRNL GVTTSTPCSP
RATLDRWGSN GKQGFFSHKK GGIPPLPPVR KSSLDQRNRA ASPLQQTTHG VSSQGNSADD
AGVSGCGPAG VTRQRGSSID SSRLFSAKLE QLANRTNSLG RVHSSHSGSH HYDCFSLERG
ESLRGGGGVK GDSTMPRTGR SLNRAGSLSS SSGNTSTKTS SQSKISAVSK LLMTSSPKAR
SLSASSTKTL SFSTKSLSQS SSRSSSLPPN GKGPAPGSWS TQSLSRSRGG SLAAKLPLRA
VNGRISELLQ GSAGSRSRSH ERAAVVQTLP SPYSKITAPR KPHRCSSGHA SDNSSVLSGE
LPPAMGKTAL FYHSGGSSGY ESMLRDSSEN TGSTSSAQDS LSEHSSATTS SRRSSRSSKK
SRSNTGLQRR RLIPALTLDS SSSSPGACWV DGPLGPPAPS NLRAVTATTE TFEIKVYEID
DVERLQKRKD KGGSKEVVYV SAKLRLLEHR QQRISEVRAK YQCLKKELEQ TKQYLMLEPH
KWTTEFELQQ AYEVDSLEYL EALETVTDKL ETRVNFCKAH LMMITCFDVS SRHQ
//
