ID A0A3P9BVC1_9CICH Unreviewed; 1069 AA.
AC A0A3P9BVC1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Unconventional myosin-Ie {ECO:0000313|Ensembl:ENSMZEP00005013586.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005013586.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005013586.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR AlphaFoldDB; A0A3P9BVC1; -.
DR Ensembl; ENSMZET00005014045.1; ENSMZEP00005013586.1; ENSMZEG00005010166.1.
DR GeneTree; ENSGT00940000165572; -.
DR Proteomes; UP000265160; Unplaced.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01378; MYSc_Myo1; 1.
DR CDD; cd11827; SH3_MyoIe_If_like; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035507; Ie/If_SH3.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF747; ZGC:64042; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 17..690
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 728..920
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT DOMAIN 1012..1069
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 567..589
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 917..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..961
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1004
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 110..117
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1069 AA; 122751 MW; 1FB5F79CEE06A952 CRC64;
QGSKERYHWQ AQNVKVSGVD DMVLLSKINE DAITDNLKKR YMDDYIFTYI GPVLISVNPF
KQLPYFTERE VELYQGAAQY ENPPHIYALA DNMYRNMMID SENQCVIISG ESGAGKTVAA
KYIMSYVSKV SGGGDKVQHV KDIILQSNPL LEAFGNAKTV RNNNSSRFGK YFEIQFSRGG
APDGGKISNF LLEKSRVVSQ NQGERNFHIY YQLLGGATTE QRENLGVTTP DYYNYLNQTG
TYTVEDVNDK KEFSDTMEAM SVVGLSLEDQ DSVLQLVAGI LHLGNISFRE ENNYAVVESQ
NFLAFPAYLL GISQDGLCSK LTSRIMDSKW GGKTESISVT LNTEQACFSR DALSKALYTR
LFDFLVDCIN KAMQKEQEEL NIGVLDIYGF EIFQQNGFEQ FCINFVNEKL QQIFIELTLK
AEQEEYVQEG IKWTPIEYFN NKVVCDLIES KLNPPGIMSI LDDVCATMHA KGEGADQTLL
QKLQGQIGSH EHFSSWNKGF IVHHYAGKVS YDVSGFCERN RDVLFNDIIE LMQSSEFPFI
RALFPENLEA EKRGRPTTAS SKIKKQANSL VQTLMKCTPH YIRCIKPNET KRSRDWEENR
VRHQVEYLGL RENIRVRRAG YAYRRVFNKF LQRYAILTKE SWPQWRGDER QGVLHLLNSV
NMDQDQFQLG KTKVFIKAPE SLFLLEEMRE RKYNGYARVI QKAWRKHVAV RKYVKMREEA
SDVVLNKKER RRNSINRNFV GDYIGTDNHP EIRQFVGRRE RIDFADVVVK YDRRFRSVKR
DLILTPKFLY MIGREKVKHG PDKGQIQEVL KRKIEINKIQ SVSLSTLQDD FFIIHEEEYD
SVLQSVFKTE FLSLLVKRYE DKTQRKLPLK FNNLLEFKVK KGGWGPFSSS GSRQIQFQVG
QGDEAVLKPS GKVLQVSIGP GLPKHSPSRS RGSGALKEGS AYSRGSLLRQ QSSMEQPTLP
RLQNQRRHDS RPHQNQDMGF MDVPDQGAAG VHRRRSKEVK PPPGAGRPKP KPRTPHCRAL
YAYDAQDTDE LSFNAEDLIE IVTEDPSGWW FGRLRGREGM FPGNYVEKI
//
