ID A0A3P9BVG8_9CICH Unreviewed; 724 AA.
AC A0A3P9BVG8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Protein Dok-7 {ECO:0000313|Ensembl:ENSMZEP00005013980.1};
GN Name=DOK7 {ECO:0000313|Ensembl:ENSMZEP00005013980.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005013980.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005013980.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005013980.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9BVG8; -.
DR Ensembl; ENSMZET00005014451.1; ENSMZEP00005013980.1; ENSMZEG00005010507.1.
DR GeneTree; ENSGT00390000015386; -.
DR Proteomes; UP000265160; LG6.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR CDD; cd13165; PTB_DOK7; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR037746; Dok-7.
DR InterPro; IPR037748; Dok-7_PTB.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR21636; PROTEIN DOK-7; 1.
DR PANTHER; PTHR21636:SF2; PROTEIN DOK-7; 1.
DR Pfam; PF02174; IRS; 1.
DR SMART; SM01244; IRS; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 4..110
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 106..211
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 326..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..420
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..716
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 77581 MW; A3CB6A295B471445 CRC64;
MTDTVVAEGQ VKFRDGKKWK TRWVVLRKPS PVADCLSLLV YKKKGKEKGS GHKERLNVTL
EGICGVEPGL GYDGVSYTLS ILCLAHMLVL GFNNRDTLLA WDARIRYSLG EVHRFSVNVE
PGTKLESGPA SLHLCNNLLV LTRGLPPVVV GHWKLSALRR YGAVPNGFVF EGGTRCGYWA
GVFFLSCSEG EQISFLFDCI VRGINPSRAP HGLQPDLPAD PSADPASAEE RINLEASVLE
KRLSMLSQCS LASSTASSYS CSTSVAGDDH SSISSSSSSQ SDASYGSRLP VWAEPLGRLH
LSSETASSSS TLKALASSDD RLYSAVVGGS RSHPSSTHIH PRGLHDSGRQ SSLDSGIGIA
TGSHSSYSGS YSSCTGSLDM ASGGVGEEFG SVASLPPAPS FPSSPPSAPP PTPPSSPFQP
MLIPEGNTAS CSCSSRSASR TSRRHSEEYR IPSLLRLWYD TPRSLLRAQP QKKPWSHGAQ
SELSKDNKSS GDGGDGQGQG GVMAQRQVMM QRSHSWGSER APSVDSEGRA TPRPLLVPGG
LFNAEKQTDS SPLMHLTPSA DSQDSPLCIR EERHDSSDIS SKLASLKKLL PSLLLHAPPP
PPVPPSMHRP TSACGMFRFS HEAPPPASQD CGPCSNSSTN YVNIPVSPLL YKTRELLYTE
LELQKPSSAP GSSPHSAERE EGSIRYAHLD ITAMETAQRV GAEHVQARED RLTQLESRRQ
GPPN
//
