ID A0A3P9BX00_9CICH Unreviewed; 1185 AA.
AC A0A3P9BX00;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Protocadherin 18 {ECO:0000313|Ensembl:ENSMZEP00005014377.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005014377.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005014377.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005014377.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9BX00; -.
DR Ensembl; ENSMZET00005014857.1; ENSMZEP00005014377.1; ENSMZEG00005010828.1.
DR GeneTree; ENSGT00940000156295; -.
DR Proteomes; UP000265160; LG6.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF9; PROTOCADHERIN-18; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1185
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018122800"
FT TRANSMEM 694..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..135
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 136..244
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 245..352
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 368..464
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 465..574
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 595..685
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 771..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 854..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 931..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1087..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1144..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..953
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..970
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1019..1056
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1087..1124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1185 AA; 129741 MW; C0B5AF528603E82C CRC64;
MKGLFLRRMW KVLAVLALAT QHITGKTLKY QIYEEQKVGT VIARLKEDVA DVLAKLPSSV
PLRFRAMQRG SSSFFNVREQ DGEISIKTKI DREKLCEKNL NCSIQFDVLT LPTEHLQLFL
IEVEVLDIND NAPQFARAVI PIEISESAAV GARIPLDSAT DPDVGENSLY SYALEPNNFF
KLDIQSRTDG VKYAELVVLR ELDREERSGY GLQYTASDRG IPLRTGSTLL KISVTDSNDN
SPVFEKSSYV INLPENSPVG TLLIDLNATD ADEGTNAKIV YSFSSHVSPK IMETFKINPD
SGHLTLIRRV DHETANSYDI DVQAQDMGPN SMPAHCKILV KVVDINDNKP DISITLMSSQ
GNGDAAYVSE ASPLDTFVAL VRVEDLDSGL NGEVECKLHG QGYFKLQKTY ENNYMILTNV
TLDREKRSEF SLTVVAEDRG TPSLSTVKHF TVHVTDENDN PPRFEKGQYE IFKSENNAPG
AYLTSILATD PDLDSNGQVS YSILENSVHG SSISTYVTID PSNGAIYALR TFDREDVSRI
AFIVQAKDAG KPALLSNATV ILNILDENDN PPVIVVPQLW NFTADVPASK FTEAGHLITV
VRATDRDTGV NAELICSIVS GNEEGFFLIE PRTCEIHANA SLDNFPHDHA ELTVVVRDQG
SESLSAKAVL KITLHETIEN HGSVTDQGEA SLDVSLIIII SLGAICVALM FIMVVFASRC
NREKKDTRHS YNCRVAESTH QHHPKKPSRQ IHKGDITLVP TVNGTLPIRA HHRSPSATPP
MERAQIGSRQ NHHSRQSLNS LVTISSNHIP ESFALELAHT TPPVEGQYQP RPSFRGNKYS
RSYRYALQDM DKFSLKDSGR GDSEAGDSDC DMGRESPVDR LLLGEGFSDL MHLEMHHRLH
PAMRLCTDEC RVLGHSDQCW MPPLSSPASS ADYRNNMYIP GEESSQQPQL DDDQSSVDSE
RRKSFSTFGK ESGNEEEGAG GVVSGAGGDV CAAGGGAGSL LTEMNSVFQR LLPPNMDSYV
ECTETSPTSS SSTTERGNGR SGNIVGNHSN NAVPQDNRRG LLPGGKGPSY PPGVAAWAAN
THYLNPGSGS GNGTNHVSSS PSSSTSSSSS PSTSTPTSTS GQPPHLKWLP AMEEIPENYE
EDDFDGVFHQ GHQSGKRSEN RHEAGMDASE LVQEINKLLQ DVRQN
//