ID A0A3P9BYI6_9CICH Unreviewed; 878 AA.
AC A0A3P9BYI6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Inter-alpha-trypsin inhibitor heavy chain H3 {ECO:0000256|ARBA:ARBA00039924};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005014954.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005014954.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005014954.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: May act as a carrier of hyaluronan in serum or as a binding
CC protein between hyaluronan and other matrix protein, including those on
CC cell surfaces in tissues to regulate the localization, synthesis and
CC degradation of hyaluronan which are essential to cells undergoing
CC biological processes. {ECO:0000256|ARBA:ARBA00037051}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the ITIH family.
CC {ECO:0000256|ARBA:ARBA00010158}.
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DR AlphaFoldDB; A0A3P9BYI6; -.
DR STRING; 106582.ENSMZEP00005014954; -.
DR Ensembl; ENSMZET00005015442.1; ENSMZEP00005014954.1; ENSMZEG00005011228.1.
DR GeneTree; ENSGT00940000154554; -.
DR Proteomes; UP000265160; LG5.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR010600; ITI_HC_C.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10338:SF115; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H3; 1.
DR Pfam; PF06668; ITI_HC_C; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 11..140
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 265..449
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 878 AA; 99197 MW; 21A1527516F11332 CRC64;
MNPRLTREET HFYLLTFSSV SLSQVEVHSV TVDCTVTSRF AHTVMTSKAF NKANSSQEIF
FEVELPKTAF ITNFSMEIEG QVYVGEVKEK EKAKKQYEKA VSSGQTAGLV KASGRKMEKF
SVSVNIAAES NVTFVLTYEE LLQRKLGRYE LLTRVKPKTL VQDFQIVTNI YEPQGISYVD
THATFLSNEL LPLVEKTVTD RKAHISFSPT MEQQRKCPGC DGTLIDGDFI VSYDVKREKN
LGDIQIVNGY FVHFFAPELP KLPKNVVFVI DISGSMSGRK MEQTREAMLA ILQQVHEDDH
FAIILFDSVI ETWKDSLTKA TKENITEAMD YIRRMNSRGA TNINDAVLTA VNMLVKDRQM
ERLPDRSADM IILLTDGMPN EGKYSNTGKI QENMRTAIGG NMSLYCLGFG NDVDYSFLDV
MSKQNKGLAR RIFEASDAAA QLQGFYDEVA SPLLLEVDMH YPDNAVDSLT TSHFSYLFNG
TEIVVAGHLM DNDLDNFLVE VVGQGLEEDF RVQGQVSAAD WDVFYPDEEY IFGDFTERLW
AYLTIQQLLD KSKSGTPDEK ANTTAKALDM SLQYNFVTPL TSMVVTKPET EDSTSSPLIA
DKLTEGTWRK QTYNYIPAQS YPRHYQPAPA YFVDGDPHFM IELPDRGDAL CFNINDKPGT
IFNLVRDSNS GILVNGEIIG DKKTPPDGKI NTYFWRFGIV HQTLGVRLEV STEDISLFQD
GKWVKLLWSD AASIKGSNVD LLVTKDRSLT VTLRDSVKFV ILLHKVWKKH PYHRDYLGFY
TLDSHLLSPG VHGLLGQFYH GINYEVAHLH PGKVPEKPDA TMYVKGQELN VTRGWQRDFR
NDVKNGENVP CWFIHNNGTG LIDGHVRDYI VSGLFKSV
//