ID A0A3P9BYJ9_9CICH Unreviewed; 655 AA.
AC A0A3P9BYJ9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Toll like receptor 2 {ECO:0000313|Ensembl:ENSMZEP00005015050.1};
GN Name=TLR2 {ECO:0000313|Ensembl:ENSMZEP00005015050.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005015050.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005015050.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005015050.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9BYJ9; -.
DR Ensembl; ENSMZET00005015539.1; ENSMZEP00005015050.1; ENSMZEG00005011279.1.
DR GeneTree; ENSGT00940000156323; -.
DR Proteomes; UP000265160; LG6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR017241; Toll-like_receptor.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF17; TOLL-LIKE RECEPTOR 2; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR PROSITE; PS51450; LRR; 2.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..655
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018060696"
FT TRANSMEM 567..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 511..565
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
SQ SEQUENCE 655 AA; 73357 MW; 5BC15F18393B268F CRC64;
SFREKVMKFL VFVLLVSQCS ALTSQQCHHC EQTSCDCSSQ NLREVPAAAS KLITELDLSL
NALETIMKDD FLSYAALRAL FKLDLSSNQL ETLSSGWFQN LTSLHYLNLL GNKYSTLGQG
NLFLPLRSLK TLHFGGPFLQ SVSKRDFSGL FGLEELVFEG NHLQVFNRGS LRQIGPISHV
TLRLSGVFHR DLAVVRAILL DVVHPNTTVT FTDTQFNKSL QMFPLHVAIE RGATGLSFKN
VNMSVSACVQ LVNIFSGSDL TFFAIEDSHI FKNEEEVRLH HINLTSLDVI VFKNIDINVF
YRVPELHFMQ NILTVVRRAS MINTMLFVIP CQSTIHFSDL EFLDISDNII GDLTLMEMMC
YGIGVLLNLR TLNISKNILS SINSKLFTRL EKLENLDMSR NSFDSMPSTC SWPASLKFLN
LSSTSLPEVT SCLPQSLQIL DLSRNKLTVF SIELPLLKEL YISGNKLGNL PDGHLYVSLA
VLSIQDNNLA KFSSKNLHDY QSLRVLEAAG NPYVCSCDFV GFVTNDLMNH KTVVRHDLKS
YICDSPNAVR GERVSDVKLS VFECRTALAI SLLCLGILVL CVLIAGLCYK FSVVGLNEGD
LGGGKCDNFV KIRLRKAMNS RTYLESPHDE DHIPAFWQSL RTAMKTSEID NKDNL
//
