ID A0A3P9C0G0_9CICH Unreviewed; 846 AA.
AC A0A3P9C0G0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Heat shock 70 kDa protein 4 {ECO:0000313|Ensembl:ENSMZEP00005015720.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005015720.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005015720.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005015720.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|ARBA:ARBA00007381}.
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DR RefSeq; XP_004541000.1; XM_004540943.3.
DR AlphaFoldDB; A0A3P9C0G0; -.
DR STRING; 106582.ENSMZEP00005015720; -.
DR Ensembl; ENSMZET00005016227.1; ENSMZEP00005015720.1; ENSMZEG00005011784.1.
DR GeneID; 101467637; -.
DR KEGG; mze:101467637; -.
DR CTD; 334086; -.
DR GeneTree; ENSGT00940000156067; -.
DR OrthoDB; 276440at2759; -.
DR Proteomes; UP000265160; LG2.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR Gene3D; 1.20.1270.10; -; 2.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR45639:SF8; HEAT SHOCK 70 KDA PROTEIN 4; 1.
DR PANTHER; PTHR45639; HSC70CB, ISOFORM G-RELATED; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 2.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT REGION 500..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..578
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 846 AA; 94602 MW; 31C40A4E86A219CF CRC64;
MSVVGFDVGF LNCYVAVARA GGIETVANEY SDRCTPACVS FGPRNRSIGA AAKSQVVTNC
KNTVQGFKKF HGRAFSDPYV QSLKENMVYD IAQMPSGTTG IKVMYMEEEK VFSIEQVTAM
LLTKLKETAE NALKKPVADC VVSVPCYYTD AERRSVVDAA QIAGLNCLRL MNETTAVALA
YGIYKQDLPA PEEKARNVVF VDLGHSGYQT SVCAFNKGKL KVLATACDPL LGGKDFDEVV
VKHFCEEFGK KYKLDVKSKP RALVRLYQES EKLKKLMSAN SSDLPLNIEC FMNDIDVTGK
MNRAQFEEMC ADILARVEPP LQSLLEQAKL KKEDIYAVEI VGGASRIPAV KERISKFFGK
ELSTTLNADE AVARGCALQC AILSPAFKVR EFSITDAVPY PISLKWHSAA EDGVSDCEVF
PKNHAAPFSK VLTFYRKEPF SLEAYYSSPN ELPYPDPTIG QFMIQKVVPQ ASGESSKVKV
KVRVNIHGIF SVSSASLVEV QKSDEAEEPM ETEQAADKDG EQSKMQTDQD EQLTQGEAQK
ETEEKTPRES EEMETSTEEN KGEKKSDQPP QAKKPKVKTK VLELPIENNP QWQLANDMLN
LFVENEGKMI MQDKLEKERN DAKNNVEEYV YEMRDKLHGM LEKFVSETDR DVLSLKLEDT
ENWLYEDGED QPKQVYIDKL AELKKLGQPI QDRYAESEER PKAFDELGKQ IQQYMKFIEA
YKMKDEQYDH LDEADVNKVD KLNNDAMIWM NSAMNQQSKQ SLAVDPSVKV KDIKAKTREL
FGACNPIVTK PKPKVELPKE ETPAEQNGPV DGQEKPQEAA ADKGTTEAAG NPASETTESK
PDMDLD
//
