ID A0A3P9C0Y2_9CICH Unreviewed; 1377 AA.
AC A0A3P9C0Y2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Adhesion G protein-coupled receptor A2 {ECO:0000313|Ensembl:ENSMZEP00005015536.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005015536.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005015536.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005015536.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR RefSeq; XP_004544345.1; XM_004544288.2.
DR STRING; 106582.ENSMZEP00005015536; -.
DR Ensembl; ENSMZET00005016037.1; ENSMZEP00005015536.1; ENSMZEG00005011663.1.
DR GeneID; 101487898; -.
DR KEGG; mze:101487898; -.
DR CTD; 25960; -.
DR GeneTree; ENSGT00940000158941; -.
DR OrthoDB; 2900279at2759; -.
DR Proteomes; UP000265160; LG12.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:1990909; C:Wnt signalosome; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0022009; P:central nervous system vasculogenesis; IEA:Ensembl.
DR GO; GO:1990791; P:dorsal root ganglion development; IEA:Ensembl.
DR GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45930:SF1; ADHESION G PROTEIN-COUPLED RECEPTOR A2; 1.
DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 762..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..818
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..851
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 878..896
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 916..936
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 997..1020
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1026..1045
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 250..352
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 335..429
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 756..1051
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1095..1122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1136..1200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1261..1288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1353..1377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1095..1120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1261..1279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1377 AA; 149575 MW; 6F682102EFD13705 CRC64;
MIGGWGAAEV RSSRRTMFAP GVGIPLLPGR LVLMLLLLPR LYQACPGLLA STSGCSCAEE
RPKLHSVQAV GIRVSCSKGE LTELPDPGLL PNRTVTLILS HNKIRVLRNG SFLGLYALDK
LDLKHNLIST IMPGAFQSLS ELRKLDLSNN RIGCLTADMF QGLTNLTKLN LSGNIISTMN
PGVFEELPSL KLVNFNSDYL TCDCELQWVP NFFRGSPARL GEETLCAYPM SLRGKPLRGL
REGHLSCDGP LELHTMSLLP SQRQVVFKGD RLPFHCAAAL VDKMTTLHWR HNGQPVTTDP
EMGVQLESSV VHDCTFITSE LILYDVHVEA SGEWECVVST GRGNKSLTVE IVVLENSASF
CPEDKVVNNR GEFRWPRTLA GITSHQYCLQ LRYPSLSVEG GMEQKKASRY CDRTGKWEDG
DYSNCHYTNG ITRVLHTFIL RPINASNVVT VAHQVRTYTL EAAGFTDSVD VLYMAQIMEK
FMEYVTQIKE LLAVMVEMGS NLMQVDEQIL ALAQREKRAC SSIVNSLETL AWSQLHSNAK
EFSMMSKNIV MEAHLIQPAH FTGITCTAHQ QREVSVGNLG METSESGHEQ QLRVHCSTGA
HNTSLNNFFL KNSVALASVT LPANLFASDA AADCKLQFVA FRTGSFFPLT GNSSTTTEHS
RRRTVNSPVV FVGLDGCSMQ NNSDPIWVSL RHLSPGTDAV AAHWSLKGPE KQGSWSQEGC
QLVRSDSNTS TMRCSLLSNY AVLQEVPDFP SSPLTVRVLH PVVYACTAVL LLCLFTIIIT
HILHHSSICI SRKSWHTLLN TCFHIAMTTA IYAGGISLTS YPVVCQAVGI ALHYSSLSTL
LWIGVSARVI YKEAVWRMPR QPDGESPVPP TQRPMLRFYL IADGVPLIIC GITAAVNVND
YGDNSPYCWL VRRSSLGSFF VPAGLVVLVT WIYFLCTVFR LRRRGAKECT GTTLSSPVTE
SHPALAGSTS LLSTDSVTGP VHPVMSPEDQ YSLKTQFSVL VATHFLFVAL WCCAAMAVWL
TGHTSLLFSC LYGIVATVLG GFLVVHHCFR RQDVQTSWLA CCPGYQRPHP MSTYTHTCTT
GSGVQTSEQG SQLFINCHPP GDSHNSSSAR SSSTPSGISS VGPGPCKLTN LLQATQDNSN
GTSRAPTGNN TSTSTDNITK PTNNVLPTIN SAAPGQPQRR KASSRTKQGS SQYYHRGEGR
GHYRLKALRA AGGGGSLGAL GPIGLDHLSS SHAVYKQATS ENGSIHHSLS ENQASVLTNG
KRVGESVATS PSEGSDGGSS GSRKPFPLLP SMASRVAMQN AQRRCASRDN LKVAASAETK
RCSYPLNGDT ATVPGAAGQN GNLKNSVLEL EQDMSGTDQS QSSVGMKSGL WKSETTV
//
