ID A0A3P9C1N1_9CICH Unreviewed; 1001 AA.
AC A0A3P9C1N1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Semaphorin 6D {ECO:0000313|Ensembl:ENSMZEP00005016022.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005016022.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005016022.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005016022.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR AlphaFoldDB; A0A3P9C1N1; -.
DR Ensembl; ENSMZET00005016535.1; ENSMZEP00005016022.1; ENSMZEG00005011901.1.
DR GeneTree; ENSGT00940000159303; -.
DR Proteomes; UP000265160; LG1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF65; SEMAPHORIN-6D; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1001
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018178364"
FT TRANSMEM 568..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..494
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 336..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..793
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..882
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1001 AA; 110433 MW; A4A2631302CAA2DD CRC64;
MGQKAVLLLS ELLLLLLTVS RTLLAVSFPE DIVPLDVVDA HFSRRYPVFR GRPSGNESQH
RLDFQLMTTI QDTLFIKLTW RSGQADREMC AVKGKHRDEC HNFIKVLVPR NDDLVFICGT
NGFNPMCRYY RLDNLEFDGE EINGLARCPF DSKQTNVALF AEGKLYSATV ADFQASDSVI
YRSMGDGSAL RTIKYDSKWL KEPHFLHAAE YGNYVYFFYR EIAVEHSNLG KVVYSRVARI
CKNDVGGSQR VLEKHWTSFV KARLNCSVPG ESFFYFDVLQ SITDIIDING VPSVVGVFTT
QMNSIPGSAV CAFSMADIEK VFLGRFKEQK TPDSVWTPFP EEKLPKPRPG SCAGHGPAAS
FKSSVEFPDD TLQFIKSHPL MDTAVPSIGD EPWFTKTRVR YRLTALAVDS EAGPHKNYTV
VFIGAESGVV LKVLAKTSTV SLNDSLLLEE IDIFNRAKCL SNREDDKRVL SLHVDKDAHS
LYVAFSSCVI RIPLSRCERH SSCHKSCIAS RDPYCGWKPH GACERIQPGV LAGYEQDVEF
GNTAHLGDCQ GVWDIQAGET NQMVHMNILI TCVFAAFLMG ALLAGLIVFC YRDSFLRKPR
HVHKDAESAP SCSDSTGSFV KLNGLFDSPV KEYQTNNDSP KLYTNLLSTG KDLNAPNGDT
KTVILRDGCQ PPELAALPTP ESTPVLQQKG LQPIKNQWER AHGKVSGSRK ESNSSAKSPQ
FLPSSPTPAN SSSHHPHLAL GHSHIPSAVV LPNATHDHPS HDNGEDTLPH SSEKKLKNPD
SKGAKKDQKR SVDARNTLND LLKHLNDSVA NPKAILQEGS VPRPRQHLTL EPMEELTEIP
PKVPSREASL YSPSSSLPRH SPTKRVDVPM PTTPTGSLSM GGTLERQRGG YQLQRSASHR
HSLSTSPNGV TMGVSVSRQH SMNRGGYMPP TPPSRLDSHG GVMAPGMHSA HPPSVSSYSG
HGSLPRTGLK RTPSIKPDVP PKPNGFSPQT PQMRVVNKYS Y
//
