ID A0A3P9C273_9CICH Unreviewed; 1319 AA.
AC A0A3P9C273;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=SOS Ras/Rho guanine nucleotide exchange factor 2 {ECO:0000313|Ensembl:ENSMZEP00005016217.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005016217.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005016217.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005016217.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 106582.ENSMZEP00005016217; -.
DR Ensembl; ENSMZET00005016733.1; ENSMZEP00005016217.1; ENSMZEG00005012159.1.
DR GeneTree; ENSGT00940000158324; -.
DR Proteomes; UP000265160; LG19.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0048793; P:pronephros development; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF150; SON OF SEVENLESS HOMOLOG 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 186..375
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 428..531
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 582..729
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 768..1007
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1008..1088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1131..1299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1059
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1135..1151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1160..1215
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1257..1272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1273..1288
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1319 AA; 151306 MW; 4C00F7DD037E265C CRC64;
HPTAASRFEY FSGGNPVQKQ VHPNLTAKED ALQYIEELIL QLLNMLCVAQ PRTVQDVDER
VQKTFPHPID KWAIADAQSA IEKRRRRHPL LLPVDKIHPL LKEVLGYKVD YHVSLYIVAV
LEYISADILK LAGNYVGNIR HFEITQQDIK VSMCADKVLM DMFDQEEDIG LMSQCAEEPL
SSGELTYDDL VRLEIAEERQ YLRELDLIVK VFRRHFLHSK VFTNEDVEVV FSNILDIHEL
TVKLLGLIED AVEMTADGSP HPLVGSCFED LAEEQAFDPY ETLSQDILGG EFHSHFNSLM
ARPTVGLYFQ SVTEGFKEAV QYILPQLMMV PVYHCMHYFE LLQQLQERSE DLDDRECLKQ
ALTALLNLQS SMERIYAKHQ PRRKPGEPMY RLYSRQIRSK QLAIKRMNEI QKSIDGWEGK
DIGQCCSEFI LEGPLIRAGA KHERHNFLFD GLMISCKANQ SSRLPGAGSG AEFRLKEKFV
LRKVSITDRE DSPELRNAFE LVAKDDTRAV FCARTAEEKE AWMAALVTLQ YRSTLDRMLD
TELQQEEQAQ PLRLPSPEVY RFAVQDSEEN IVFEDKVQSK TGIPIIKAGT VDKLIERLTY
HMYADPNFVR TFLTTYRSFC KPHEFLTLLI DRLTIPDPEP TDEDRQILMT NDHPMVAQLQ
RFRKEYVQPV QLRVLNVFRQ WVEHHFYDFE NDAELRSRLE EYFTTKIQLR GKSMRKWVES
INKIIRRKMQ PQTNGVSPSI TFESSPPSIE WHICRSGQLE LFDLMTLHPI EIARQLTLIE
SELYRAVRPS ELVGSVWTKE DKEKHSPNLL RMIRHTTNLT LWFEKCIVET MNLEERVAVF
TRVIEILQVF QELNNFNGVL EVLSAINSVA VYRLDHTYEA VPERKRKILE EAAELSKDHF
KKYLAKLKSI NPPCVPFFGI YLTNILKTEE GNPDFLKRHG KDLINFSKRR KVAEITGEIQ
QYQNQPYCLK VEPEMRKFFE NLNPMGNLSE KEFTDYLFRK SLEIEPRNCR QPPRFPRKTV
YSLKSPGIRP VRTSTSGTLK GHPVPLERDP PHKITFRSIN ENDSESLVSV PTSPNTPTPP
QSATPDFNSV FTEHDQLSNS YGGDFFIRFN PCFPFSSELQ SASCGSLHHL GEELKPPPLP
PRRKDTMSDT KVRAVSDSPP AIPPRVPPPL HRNQPRPPVY NGPPTDGPLP SPPPPPPPRD
PIPDTPPPVP QRPPEIFINY PVNQPSPVGR YTWDYGSSPS SPNTPPSTPS PRIARRGCSL
SASQNSLCPL SIPTSAPPVP PRYNSSPHLP KLPPKTYKRE LLQAPVQSLS LVENTDSSH
//
