ID A0A3P9C276_9CICH Unreviewed; 1334 AA.
AC A0A3P9C276;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Regulatory associated protein of MTOR complex 1 {ECO:0000313|Ensembl:ENSMZEP00005015991.1};
GN Name=RPTOR {ECO:0000313|Ensembl:ENSMZEP00005015991.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005015991.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005015991.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005015991.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat RAPTOR family.
CC {ECO:0000256|ARBA:ARBA00009257}.
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DR RefSeq; XP_004538834.1; XM_004538777.3.
DR Ensembl; ENSMZET00005016502.1; ENSMZEP00005015991.1; ENSMZEG00005011947.1.
DR GeneID; 101472178; -.
DR CTD; 57521; -.
DR GeneTree; ENSGT00640000091541; -.
DR OrthoDB; 103066at2759; -.
DR Proteomes; UP000265160; LG6.
DR GO; GO:0031931; C:TORC1 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR004083; Raptor.
DR InterPro; IPR029347; Raptor_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR12848; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR PANTHER; PTHR12848:SF16; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR Pfam; PF02985; HEAT; 2.
DR Pfam; PF14538; Raptor_N; 1.
DR Pfam; PF00400; WD40; 1.
DR PRINTS; PR01547; YEAST176DUF.
DR SMART; SM01302; Raptor_N; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 56..209
FT /note="Raptor N-terminal CASPase-like"
FT /evidence="ECO:0000259|SMART:SM01302"
FT REGION 696..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 856..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..946
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1334 AA; 149612 MW; 8CB805C0D3995C8E CRC64;
MKMDSDLLHS PAVGLAEEEE ADMNDWKLPL AFMKKRHSEK IEGSKALAQS WRMKDRMKTV
SVALVLCLNV GVDPPDVVKT SPCARLECWI DPLSMSPQKA LETIGANLQK QYENWQPRAR
YKQSLDPTVD EVKKLCTSLR RNAKEERVLF HYNGHGVPRP TVNGEIWVFN KNYTQYIPLS
IYDLQTWMGS PSIFVYDCSN AGIIVKSFKQ FALQREQELE VAAINPSHPL AQMPLPPSMK
NCIQLAACEA SELLPMNPDL PADLFTSCLT TPIKIALRWF CMQKSAKLVP GVTLDLIEKI
PGRLNDRRTP LGELNWIFTA ITDTIAWNVL PRDLFQKLFR QDLLVASLFR NFLLAERIMR
SYNCTPVSSP RLPPTYMHAM WQAWDLAVDI CLSQLPTIIE EGTAFRHSPF FAEQLTAFQV
WLTMGVENRN PPEQLPIVLQ VLLSQVHRLR ALDLLGRFLD LGPWAVSLAL SVGIFPYVLK
LLQSSARELR PLLVFIWAKI LAVDSSCQAD LVKDNGHKYF LSVLADNYMP AEHRTMAVFI
LAVIVNNYTT GQEACLQGNL IANCLEQLSD PHPLLRQWVA ICLGRIWQNF DPARWCGVRD
SAHEKLYTLL SDPIPEVRCA AVFALGTFVG NSAERTDHST TIDHNVAMML AQLINDGSPV
VRKELVVALS HLVVQYESNF CTVALQFIEE EKNYSVPSPA NTAEPGNLTP VRDSPAIPRL
RSVNSYTNIR TATTARNLNK SLQNLNLNEE GGPAAFSPGN LSTSSSASST LGSPDNDEYI
LSFETIDKMR RVSSYSSLNS LIGVSFNSVY TQIWRVLLHL AADPFPEVSD LAMKVLNSIA
YKATMNARPQ RILDSGSLTQ SAPASPTSKG THIHQAGGSP PMPSTSSSSL TNDVPKPPTR
EQPATRPPYT PTLGGQAPHS HQFTRTRKMF DKGPEQAAED SDEPGGHRNY ISPALQTGLC
DWSAKYFAQP VMKIPEEHDL ESQVRLERQW RFLRNARVRR QSRSIIQRGI SRLDDQIFIN
RNPGVPSVVK FHPFNTCIAV ADKDSICFWD WEKGERLDYF YNGNPRYTRI TSMEYLNGHD
CSLLLTATDD GALRIWKNFA DQKNPEMVTA WQGLSDMLPT TRGAGMVVDW EQETGFLMTS
GDVRVVRIWD TDREMKVQDI PTGADSCVTS LSCDSQRSLI VAGLGDGSVR VFDRRMGPNE
CRVMTYREHG AWVVKAHLQK ETDGHIISVS VNGDVRFFEP RMPESINVLQ TVKGLTALDI
HPQANLFACG SMNQFIAVYN ANGDVISNIK YYDGFMGQRI GAISCLAFHP HWPHLAVGSN
DYYMSIYSAE KRLR
//
